Acute Lymphoblastic Leukemia in Children

TL;DR: A 7-year-old boy discovered to have elevated transaminase levels while undergoing an evaluation for motor tics, which subsequently progressed to cholestasis and acute liver failure secondary to acute lymphoblastic leukemia, and is in clinical remission.

TL;DR: In this article , the effects of T-cell immunity on Ph+ ALL therapy outcomes were evaluated using a murine Arf−/−BCR-ABL1 B-cell ALL model, and it was shown that loss of T cells in the host drastically increased leukemia relapse after dasatinib or cytotoxic chemotherapy.

TL;DR: Health professionals should predict and prepare for psychiatric adverse events prior to chemotherapy in the clinical settings, especially in patients in younger age and receiving a treatment regimen with dexamethasone, according to independent risk factors and characteristics for clinical symptoms of CIPDs during the developmental process.

TL;DR: The National Cancer Policy Forum (NCPF) held a workshop on combining immunotherapy and checkpoint inhibitors for cancer as mentioned in this paper, focusing on the challenges and opportunities to develop combination cancer therapies that include immune checkpoint inhibitors.

TL;DR: A research initiative that aims to accelerate progress toward a new era of precision medicine, with a near-term focus on cancers and a longer-term aim to generate knowledge applicable to the whole range of health and disease.

TL;DR: Survivors of childhood cancer have a high rate of illness owing to chronic health conditions, including severe, disabling, or life-threatening conditions or death due to a chronic condition.

TL;DR: Imatinib induced high rates of cytogenetic and hematologic responses in patients with chronic-phase CML in whom previous interferon therapy had failed, and CML had not progressed to the accelerated or blast phases after a median follow-up of 18 months.