Journal Article10.1038/296811A0
Actin-binding proteins--regulators of cell architecture and motility.
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TL;DR: Some of the proteins described here combine the properties of more than one class and the activities of many of them are regulated by changes in Ca2+ ion concentration.
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Abstract: Numerous actin-binding proteins from a variety of cell types have been described. Here I attempt to correlate the properties and functions of some of these. Three major classes have been identified: (1) cross-linking proteins which form filament bundles or isotropic gels; (2) proteins which cap filament ends and nucleate the polymerization of G-actin (many of these also sever actin filaments); (3) proteins which bind to G-actin and stabilize the monomer pool. Some of the proteins described here combine the properties of more than one class and the activities of many of them are regulated by changes in Ca2+ ion concentration.
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Helen L. Yin,Thomas P. Stossel +1 more
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Joël Vandekerckhove,Klaus Weber +1 more
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TL;DR: It is found that the net result of four association and four dissociation steps is a lengthening of the filament by one protomer at one end and a corresponding shortening at the other.
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