Journal Article10.1016/S0968-0896(99)00306-5
Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives.
Angela Rampa,Alessandra Bisi,Federica Belluti,Silvia Gobbi,Piero Valenti,Vincenza Andrisano,Vanni Cavrini,Andrea Cavalli,Maurizio Recanatini +8 more
93
TL;DR: It is derived that the indenoquinoline nucleus probably represents the maximum allowable molecular size for rigid compounds binding to AChE, and seems particularly important in the context of Alzheimer's disease research in the light of recent observations showing that peripheral A ChE inhibitors might decrease the aggregating effects of the enzyme on the beta-amyloid peptide (betaA).
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About: This article is published in Bioorganic & Medicinal Chemistry. The article was published on 01 Mar 2000. The article focuses on the topics: Acetylcholinesterase.
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Recent synthetic developments in a powerful imino Diels–Alder reaction (Povarov reaction): application to the synthesis of N-polyheterocycles and related alkaloids
TL;DR: In this paper, a review is devoted to the development in Povarov reaction and focuses on new efficient approaches based on this reaction to construct simple substituted (tetrahydro)quinolines and diverse N -polyheterocycles, including some alkaloids, which contain pyrroloquinoline or cyclopentaquinoline ring systems.
507
SAR of 9-Amino-1,2,3,4-tetrahydroacridine-Based Acetylcholinesterase Inhibitors: Synthesis, Enzyme Inhibitory Activity, QSAR, and Structure-Based CoMFA of Tacrine Analogues
Maurizio Recanatini,Andrea Cavalli,Federica Belluti,Lorna Piazzi,Angela Rampa,Alessandra Bisi,Silvia Gobbi,Piero Valenti,Vincenza Andrisano,Manuela Bartolini,Vanni Cavrini +10 more
TL;DR: This study attempted to derive a comprehensive SAR picture for the class of acetylcholinesterase (AChE) inhibitors related to tacrine, a drug currently in use for the treatment of the Alzheimer's disease.
159
Microwave-assisted synthesis – Catalytic applications in aqueous media
TL;DR: In this article, a review of microwave-assisted catalytic reactions performed in aqueous media for the development of environmentally benign protocols is presented for the synthesis of a variety of heterocycles, crosscoupling reactions, C H activation reactions, synthesis of peptides, ureas, and carboxyl-containing coordination polymers.
159
Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors
Ali Asadipour,Masoumeh Alipour,Mona Jafari,Mehdi Khoobi,Saeed Emami,Hamid Nadri,Amirhossein Sakhteman,Alireza Moradi,Vahid Sheibani,Farshad Homayouni Moghadam,Abbas Shafiee,Alireza Foroumadi,Alireza Foroumadi +12 more
TL;DR: The kinetic study revealed that compound 10c exhibited mixed-type inhibition against AChE, and protein-ligand docking study demonstrated that the target compounds have dual binding site interaction mode, in agreement with kinetic study.
113
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