Journal Article10.1016/S0891-5849(99)00027-1
Acetaldehyde (CH3CHO) production in rodent lung after exposure to metal-rich particles.
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TL;DR: The hypothesis that metals on PM may mediate lung responses through induction of lipid peroxidation and carbonyl formation is supported, and an increased formation of Ch3CHO was observed in a human airway epithelial cell line incubated with ROFA suggesting a pulmonary source of CH3CHO production.
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About: This article is published in Free Radical Biology and Medicine. The article was published on 01 Jun 1999. The article focuses on the topics: Lung injury & Environmental exposure.
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Oxidative interactions of synthetic lung epithelial lining fluid with metal-containing particulate matter
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Carbon nanotubes and other fullerene-related nanocrystals in the environment: A TEM study
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References
Determination of carbonyl content in oxidatively modified proteins.
Rodney L. Levine,Donita Garland,Cynthia N. Oliver,Adolfo Amici,Isabel Climent,Anke-G. Lenz,Bong-Whan Ahn,Shmuel Shaltiel,Earl R. Stadtman +8 more
TL;DR: This chapter discusses methods to determine carbonyl content in oxidatively modified proteins and quantitated protein-bound pyruvoyl groups through formation of a Schiff base with p-aminobenzoic acid followed by reduction with cyanoborohydride.
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Acute respiratory effects of particulate air pollution
Douglas W. Dockery,C. A. Pope +1 more
TL;DR: In the 1930s, 40s, and 50s, several episodes of extreme air pollution focused attention on the potential for adverse health effects of air pollution, and the increased mortality associated with such episodes provided the first quantitative measure of the adverse effects ofAir pollution.
2.3K
Reactive oxygen-mediated protein oxidation in aging and disease.
TL;DR: It is established that oxidatively damaged protein is associated with aging and some diseases and nitration of tyrosine residues may contribute to peroxynitrite toxicity, as nitration precludes the phosphorylation or nucleotidylation of tyosine residues and thereby seriously compromises one of the most important mechanisms of cellular regulation and signal transduction.
896
Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent
TL;DR: It is demonstrated that metals present in ROFA may be responsible for production and release of inflammatory mediators by the respiratory tract epithelium and suggested that these mediators may contribute to the toxic effects of particulate air pollutants reported in epidemiology studies.
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What are people dying of on high air pollution days
TL;DR: Evidence is added that dead-on-arrival deaths and deaths outside of hospitals and clinics were disproportionately increased and the age pattern of the relative risk of death was similar, which adds to the evidence that the association is causal.
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