Open AccessJournal Article
Abstract 12412: Platelet Isoprostane Over-Production Enhances Platelet Function in Diabetic Patients Treated with Aspirin
Pasquale Pignatelli,Roberto Cangemi,Roberto Carnevale,Carmen Nigro,Francesco Angelico,Davide Lauro,Stefania Basili,Francesco Violi +7 more
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TL;DR: Aspirin modestly influences cardiovascular events in type 2 diabetic patients but the reason for this influence is unclear.
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Abstract: Background- Aspirin modestly influences cardiovascular events in type 2 diabetic (T2DM) patients but the reason is unclear. We investigated whether in T2DM patients aspirin enhances platelet isopro...
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Citations
Immediate Antioxidant and Antiplatelet Effect of Atorvastatin via Inhibition of Nox2
Pasquale Pignatelli,Roberto Carnevale,Daniele Pastori,Roberto Cangemi,Laura Napoleone,Simona Bartimoccia,Cristina Nocella,Stefania Basili,Francesco Violi +8 more
TL;DR: This study provides the first evidence that atorvastatin acutely and simultaneously decreases oxidative stress and platelet activation by directly inhibiting platelet Nox2 and ultimately platelet isoprostanes and thromboxane A2.