Journal Article10.1023/A:1018816622510
Absorptive function following small intestinal transplantation.
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TL;DR: All studies involving small intestinal transplantation and absorptive function are reviewed and conclusions regarding the major absorptive defects are drawn.
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Abstract: All studies involving small intestinaltransplantation and absorptive function are reviewed.The effects ischemia-reperfusion, lymphatic disruption,denervation, rejection, immunosuppressive medication, and infection are elucidated as far as thestudies allow. Species differences are discussed.Conclusions regarding the major absorptive defects aredrawn.
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Citations
The current status of intestinal transplantation.
TL;DR: The role of intestinal transplantation in the overall management of intestinal failure continues to evolve as its outcomes progressively improve and the risk factors for parenteral nutrition therapy failure become better defined.
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Intestinal transplantation: current status
TL;DR: Intestine transplant should be considered earlier in intestinal failure patients who are at high risk for developing PNALD and other life-threatening complications, and current 1-year patient survivals for intestine-only transplants are now similar to those for liver transplant.
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Optimal Management of the Post–Intestinal Transplant Patient
TL;DR: The most striking finding was in the level of agreement between the centers, particularly with regard to use of tacrolimus for maintenance immunosuppression, methylprednisone boluses for treatment of acute rejection, early postoperative enteral feeding, and ganciclovir prophylaxis.
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Intestinal transplantation: indications, results and strategy.
TL;DR: According to the current results, this challenging procedure may be performed in children or adults, only under certain conditions, and has had a slow learning curve.
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Small bowel review: normal physiology part 2.
TL;DR: Clinical learning points include the following: numerous peptides are being identified which stimulate the proliferation and functional response of the small intestine to disease or resection, and may in time find a clinical use.
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References
The enteric nervous system
TL;DR: The structural similarities and functional differences between regions may have an evolutionary basis and the physiological control of enteric neurons and development of function is studied.
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The Enteric Nervous System
Raj K. Goyal,Ikuo Hirano +1 more
TL;DR: In the past decade, major advances in the understanding of the enteric nervous system have led to a greater appreciation of its importance in clinical medicine and in this review, some of these advances are highlighted.
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Kidney transplantation under FK 506.
Thomas E. Starzl,John J. Fung,Mark L. Jordan,Ron Shapiro,Andreas G. Tzakis,Jerry McCauley,James R. Johnston,Y. Iwaki,Ashok Jain,M. Alessiani,Satoru Todo +10 more
TL;DR: The experimental immunosuppressive drug FK 506 was given to 36 renal transplant recipients, many of whom were highly sensitized, and the seeming safety, efficacy, and relative freedom from side effects of FK506 encourage further trials in kidney transplantation.
Intestinal transplantation in composite visceral grafts or alone.
Satoru Todo,Andreas G. Tzakis,Kareem Abu-Elmagd,Jorge Reyes,K. Nakamura,A. Casavilla,Rick Selby,Bakr Nour,Harlan I. Wright,John J. Fung,Anthony J. Demetris,David H. Van Thiel,Thomas E. Starzl +12 more
TL;DR: Under FK 506-based immunosuppression, the entire cadaver small bowel except for a few proximal and distal centimeters was translated to 17 randomly matched patients, of whom two had antigraft cytotoxic antibodies (positive cross-match).
D-xylose testing: a review.
TL;DR: The 1-h serum test after administration of 5 g of D-xylose should be used in pediatrics and is greater than 91% sensitive and close to 100% specific and has been useful in identifying malabsorption caused by bacterial overgrowth in the small intestine.
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