Patent
Abl-interactor protein
Ann Marie Pendergast,Zonghan Dai +1 more
- 25 Oct 1996
10
TL;DR: The present paper relates to a protein that interacts with the cAbl protein tyrosine kinase and to a nucleic acid sequence encoding the same as mentioned in this paper, and also relates to complexes of the protein of the invention and cABL and to the use of such complexes in the identification of therapeutic and diagnostic agents.
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Abstract: The present invention relates to a protein that interacts with the cAbl protein tyrosine kinase and to a nucleic acid sequence encoding same. The invention also relates to complexes of the protein of the invention and cAbl and to the use of such complexes in the identification of therapeutic and diagnostic agents.
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References
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
E. Lowenstein,Roger J. Daly,A. Batzer,W. Li,B. Margolis,Richard L. Lammers,Axel Ullrich,Edward Y. Skolnik,Dafna Bar-Sagi,Joseph Schlessinger +9 more
TL;DR: Results suggest that GRB2/sem-5 plays a crucial role in a highly conserved mechanism for growth factor control of ras signaling.
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Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho
TL;DR: The 3BP-1 protein may be a mediator of SH3 function in transformation inhibition and may link tyrosine kinases to Ras-related proteins.
532
Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents
Surender Kharbanda,Ruibao Ren,Pramod Pandey,Timothy D. Shafman,Stephen M. Feller,Ralph R. Weichselbaum,Donald Kufe +6 more
TL;DR: It is shown that ionizing radiation activates c-Abl and this findings indicate that c-abl is involved in the stress response to DNA-damaging agents.
512
SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl
TL;DR: The Src homology domains SH2 and SH3 are modular components present in many signal transduction proteins that allow rapid formation of stable protein complexes and may also regulate protein function through intramolecular binding events.
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Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain.
TL;DR: Affinity chromatography experiments show that the homeo domain amino terminus/helix 1 region is able to mediate direct interactions between HOX proteins in solution, which indicates that specificity of HOX protein function in vivo depends on both DNA-protein and protein-protein interactions, mediated by the same sub region of theHomeo domain.