A Unique Fungal Two-Component System Regulates Stress Responses, Drug Sensitivity, Sexual Development, and Virulence of Cryptococcus neoformans
TL;DR: This work characterized a fungal "two-component" system that controls these fundamental cellular functions via the Pbs2-Hog1 MAPK cascade and highlights unique adaptations of this global two-component MAPK signaling cascade in a ubiquitous human fungal pathogen.
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Abstract: The stress-activated mitogen-activated protein kinase (MAPK) pathway is widely used by eukaryotic organisms as a central conduit via which cellular responses to the environment effect growth and di...
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Citations
A sensor kinase controls turgor-driven plant infection by the rice blast fungus
Lauren S. Ryder,Lauren S. Ryder,Yasin F. Dagdas,Yasin F. Dagdas,Yasin F. Dagdas,Michael J. Kershaw,Chandrasekhar Venkataraman,Anotida Madzvamuse,Xia Yan,Xia Yan,Neftaly Cruz-Mireles,Darren M. Soanes,Míriam Osés-Ruiz,Míriam Osés-Ruiz,Vanessa Styles,Jan Sklenar,Frank L.H. Menke,Nicholas J. Talbot,Nicholas J. Talbot +18 more
TL;DR: The histidine–aspartate kinase Sln1 acts as a molecular sensor of turgor in appressoria of the rice blast fungus Magnaporthe oryzae, enabling penetration of the host leaf cuticle and plant infection.
The response regulator RRG-1 functions upstream of a mitogen-activated protein kinase pathway impacting asexual development, female fertility, osmotic stress, and fungicide resistance in Neurospora crassa
TL;DR: The data indicate that RRG-1 controls vegetative cell integrity, hyperosmotic sensitivity, fungicide resistance, and protoperithecial development through regulation of the OS-4/OS-5/ OS-2 MAPK pathway.
The HOG1-like MAP kinase Sak1 of Botrytis cinerea is negatively regulated by the upstream histidine kinase Bos1 and is not involved in dicarboximide- and phenylpyrrole-resistance.
TL;DR: Bos1 negatively regulates Sak1 phosphorylation and that Bos1 regulates certain phenotypes independently of Sak1, which include fungicide susceptibility, adaptation and conidiation on high neutral osmolarity.
105
The future of antifungal drug therapy: novel compounds and targets.
Caroline Mota Fernandes,Deveney Dasilva,Krupanandan Haranahalli,J. Brian McCarthy,John P. Mallamo,Iwao Ojima,Maurizio Del Poeta +6 more
TL;DR: A comprehensive summary of compounds aimed at one or more novel molecular targets, as well as potential pathways relevant for fungal pathogenesis that can be considered for drug development in the near future are described.
92
Specialized and shared functions of the histidine kinase- and HOG1 MAP kinase-mediated signaling pathways in Alternaria alternata, a filamentous fungal pathogen of citrus.
Ching-Hsuan Lin,Kuang-Ren Chung +1 more
TL;DR: Cl cloning and characterization of a gene coding a Group III histidine kinase (AaHSK1) and the yeast HOG1 ortholog showed the two genes to operate, both uniquely and synergistically, in a number of physiological and pathological functions.
90
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C. Stan Tsai
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The genome sequence of the rice blast fungus Magnaporthe grisea
Ralph A. Dean,Nicholas J. Talbot,Daniel J. Ebbole,Mark L. Farman,Thomas K. Mitchell,Marc J. Orbach,Michael R. Thon,Resham Kulkarni,Resham Kulkarni,Jin-Rong Xu,Huaqin Pan,Nick D. Read,Yong-Hwan Lee,Ignazio Carbone,Doug Brown,Yeonyee Oh,Nicole M. Donofrio,Jun Seop Jeong,Darren M. Soanes,Slavica Djonovic,Elena A. Kolomiets,Cathryn J. Rehmeyer,Weixi Li,Michael W. Harding,Soonok Kim,Marc-Henri Lebrun,Heidi U. Böhnert,Sean J. Coughlan,Jonathan Butler,Sarah E. Calvo,Li-Jun Ma,Robert Nicol,Seth Purcell,Chad Nusbaum,James E. Galagan,Bruce W. Birren +35 more
TL;DR: The draft sequence of the M. grisea genome is reported, reflecting the clonal nature of this fungus imposed by widespread rice cultivation and analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease.