A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation.
Zizhen Yao,Cindy T. J. van Velthoven,Thuc Nghi Nguyen,Jeff Goldy,Adriana E. Sedeno-Cortes,Fahimeh Baftizadeh,Darren Bertagnolli,Tamara Casper,Megan Chiang,Kirsten Crichton,Songlin Ding,Olivia Fong,Emma Garren,Alexandra Glandon,Nathan W. Gouwens,James Gray,Lucas T. Graybuck,Michael Hawrylycz,Daniel Hirschstein,Matthew Kroll,Kanan Lathia,Changkyu Lee,Boaz P. Levi,Delissa McMillen,Stephanie Mok,Thanh Pham,Qingzhong Ren,Christine Rimorin,Nadiya V. Shapovalova,Josef Sulc,Susan M. Sunkin,Michael Tieu,Amy Torkelson,Herman Tung,Katelyn Ward,Nick Dee,Kimberly A. Smith,Bosiljka Tasic,Hongkui Zeng +38 more
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TL;DR: The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in perception, cognition, emotion, and learning as discussed by the authors, and a transcriptomic cell type taxonomy revealing a comprehensive repertoire of glutamatergic and GABAergic neuron types.
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About: This article is published in Cell. The article was published on 10 Jun 2021. and is currently open access.
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Citations
Isolation of Pure Disease Specific Aging Trajectories in Spatial Transcriptomics via the Delta–Delta Method
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- 03 Oct 2025
TL;DR: Researchers introduce the Delta-Delta Method, a framework that isolates pure disease-specific aging trajectories in spatial transcriptomics by subtracting normal aging from disease-driven transcriptional change, enabling the identification of disease-specific molecular programs in neurodegeneration.
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Pyramidal cell types and 5-HT2A receptors are essential for psilocybin's lasting drug action
Ling-Xiao Shao,Clara Liao,Pasha A. Davoudian,Neil K. Savalia,Quan Jiang,Cassandra Wojtasiewicz,Dun Xian Tan,Jack D. Nothnagel,Rongjian Liu,Samuel C. Woodburn,Olesia M. Bilash,Hail Kim,Alicia Che,Alex C. Kwan +13 more
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