A Task-Specific Ionic-Liquid-Mediated Solvent-Free Protocol for Direct Access to Dimethyl Acetal Protected Benzimidazole 2-Carboxaldehydes
Barnali Deb,Ankita Chakraborty,Jewel Hossain,Swapan Majumdar +3 more
- 01 Oct 2020
- Vol. 04, Iss: 04, pp 89-95
TL;DR: The present protocol offers several advantages over existing protocols, such as single-step process, short reaction times, very mild reaction conditions, high yields, ease of purification, recovery and reusability of the catalyst, and scale-up of the reaction.
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Abstract: A robust and straightforward protocol has been developed for the synthesis of a diverse array of dimethyl acetal protected benzimidazole-2-carboxaldehydes by reacting various 2-amino aniline derivatives with methyl 4,4-dimethoxy-3-oxobutanoate using the task-specific imidazolium ionic liquid (HBIm·TFA) as a promoter for N-C/C-N annulation processes. The present protocol offers several advantages over existing protocols, such as single-step process, short reaction times, very mild reaction conditions, high yields, ease of purification, recovery and reusability of the catalyst, and scale-up of the reaction.
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Citations
Recent achievements in the synthesis of benzimidazole derivatives
Nguyen Thi Chung,Vo Cong Dung,Dau Xuan Duc +2 more
TL;DR: Recent achievements in the synthesis of benzimidazole derivatives focus on the condensation between 1,2-benzenediamine and aldehydes, while novel methods have been developed.
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Various approaches for the synthesis of benzimidazole derivatives and their catalytic application for organic transformation
TL;DR: This review synthesizes benzimidazole derivatives via condensation and nucleophilic substitution reactions, highlighting their catalytic applications in oxidation reactions, including olefin and alcohol oxidation, and their potential in catalysis.
5
An Insight into the Recent Synthetic Approaches of Benzimidazole Motifs Based on Divergent Substrate Scope
Kavya G,Ajil R. Nair,Akhil Sivan +2 more
TL;DR: The synthesis of benzimidazoles from o-Phenylenediamine (OPD) has been extensively studied in the literature as discussed by the authors , where a review report covers research findings which are published from 2016 till date and describes numerous practical and greener methods of synthesis.
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TL;DR: In this paper, a benzimidazole-based rigid ligand, 9,10-bis(N-benzimidel)anthracene (L), has been designed and used to react with CuI, AgI, CdII, MnII salts, giving rise to five new metal-organic coordination architectures, [CuLI]2·2CHCl3·H2O (1), [CdL2(NO3)2]·4C2H5OH (2), [AgL(BF4)]·3CHCl
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