A systematic survey identifies prions and illuminates sequence features of prionogenic proteins

TL;DR: It is suggested that, in energy-depleted cells, Sup35 forms supramolecular assemblies that differ from the Sup35 liquid droplets that form in vitro.

TL;DR: The molecular detail of Def1 activation in response to DNA damage in Saccharomyces cerevisiae is focused on, which allows it to bind RNAPII and recruit the Elongin-Cullin complex.

TL;DR: It is demonstrated that cytosolic protein aggregates can also behave as infectious entities in mammalian cells and can be induced in primary astrocytes, neurons, and organotypic cultures, demonstrating that this phenomenon is not specific to immortalized cells.

TL;DR: This recent progress based on study of two model systems, the gill-withdrawal reflex of Aplysia and hippocampal based spatial memory storage in the mouse, is summarized.

TL;DR: A new term "prion" is proposed to denote a small proteinaceous infectious particle which is resistant to inactivation by most procedures that modify nucleic acids.

TL;DR: Thioflavine T associates rapidly with aggregated fibrils of the synthetic β/A4‐derived peptides β( 1–28) and β(1–40), giving rise to a new excitation maximum at 450 nm and enhanced emission at 482 nm, as opposed to the 385 nm and 445 nm of the free dye.

TL;DR: The LiAc/SS‐DNA/PEG method was shown to be more effective than other treatments known to make cells transformable and caused tighter binding of 32P‐labelled plasmid DNA than did double‐stranded (DS) carrier.