A systematic survey identifies prions and illuminates sequence features of prionogenic proteins
Simon Alberti,Randal Halfmann,Oliver D. King,Oliver D. King,Atul Kapila,Susan Lindquist,Susan Lindquist +6 more
TL;DR: A bioinformatic proteome-wide survey for prionogenic proteins in S. cerevisiae found an unexpected amino acid bias in aggregation-prone candidates and discovered that 19 of these could also form prions.
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About: This article is published in Cell. The article was published on 03 Apr 2009. and is currently open access. The article focuses on the topics: Fungal prion.
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Citations
Novel Genetic and Epigenetic Suppressors of Nonsense Mutations
Anton A. Nizhnikov
- 01 Jan 2013
TL;DR: Nine novel genetic suppressors of nonsense mutations are described and one epigenetic suppressor is characterized, which has the properties of a yeast prion, which is suggested to be part of the system of translation termination contains a number of precisely interacting genetic and epigenetics regulators.
•Dissertation
Exploring the de novo Establishment of [PSI+] Prion Variants and the Role of a Heterologous Prion
Jaya Sharma
- 28 Jun 2013
TL;DR: The basis of [PIN] variant differences in [PSI] induction (in preparation) is explored, and the results suggest that the prion variants established in Yeast are different from those established in Proceedings of the National Academy of Sciences.
N-terminal region of <i>Drosophila melanogaster</i> Argonaute2 forms amyloid-like aggregates
Sotaro Uemura,Carlo Pellicia +1 more
- 05 Aug 2022
TL;DR: In this paper , the N-terminal region of Drosophila melanogaster (DmAgo2) has been shown to function as a prion-like domain (PrLD) for RNA silencing.
Current methods for studying intracellular liquid-liquid phase separation.
Amber R. Titus,Edgar E. Kooijman +1 more
TL;DR: In this article, the authors highlight recent advances in the understanding of intracellular phase transitions along with current methods used to identify liquid-liquid phase separation (LLPS) in vitro and model LLPS in situ.
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