A systematic survey identifies prions and illuminates sequence features of prionogenic proteins

TL;DR: This work attempted to explore whether membraneless organelles can interact with membranes by NMR HSQC titrations of three FUS domains with gradual addition of DMPC/DHPC bicelle, which mimics the bilayer membrane.

TL;DR: New evidence is emerging that Sis1 is important for processes that may not involve prion replication activity, providing an intriguing alternative explanation for the observed differences in the prions’ reliance on Sis 1.

TL;DR: In this article , the authors demonstrated a critical role of aggregated FUS in astrocyte activation caused by cerebral ischemia and a possible underlying molecular mechanism, and proposed that aggregation of FUS is an alternative pathomechanism of ischemic stroke and targeting FUS aggregates might be of unique therapeutic value in the development of future treatment strategies.

TL;DR: In this paper , the histone H3 modification landscape in the context of the [SWI+] and [PIN+] prion states was mapped to histone post-translational modifications.

TL;DR: A new term "prion" is proposed to denote a small proteinaceous infectious particle which is resistant to inactivation by most procedures that modify nucleic acids.

TL;DR: Thioflavine T associates rapidly with aggregated fibrils of the synthetic β/A4‐derived peptides β( 1–28) and β(1–40), giving rise to a new excitation maximum at 450 nm and enhanced emission at 482 nm, as opposed to the 385 nm and 445 nm of the free dye.

TL;DR: The LiAc/SS‐DNA/PEG method was shown to be more effective than other treatments known to make cells transformable and caused tighter binding of 32P‐labelled plasmid DNA than did double‐stranded (DS) carrier.