A systematic survey identifies prions and illuminates sequence features of prionogenic proteins

TL;DR: In this article, the authors describe mutated htt-exon1 analogs containing only 22-24 glutamine residues that deliver atypical aggregation: a "hyper-amyloid" analog that aggregates into amyloid fibrils comparable to pathogenic huntingtin, and "hypo-AMyloid analogs whose aggregation stops at the non-β oligomer stage".

TL;DR: In this paper, the polyasparagine (polyN) domain plays a subtle role in transcription but is dispensable for Azf1p localization and prion formation, and the polyN domain may be a useful target for engineering yeast strains for fermentation applications and small molecule production.

TL;DR: This study demonstrates that in general these prion-like proteins do not cause toxicity under normal conditions, and in fact they can protect cells through indirect mechanisms which up-regulate cellular defense pathways.

TL;DR: The sting of rejection from the Chicago intellectual-property office may have dulled, but Lindquist recognizes and is dismayed by what she sees as a growing incivility among colleagues, a meanness that she thinks threatens the progress of science.

TL;DR: A new term "prion" is proposed to denote a small proteinaceous infectious particle which is resistant to inactivation by most procedures that modify nucleic acids.

TL;DR: Thioflavine T associates rapidly with aggregated fibrils of the synthetic β/A4‐derived peptides β( 1–28) and β(1–40), giving rise to a new excitation maximum at 450 nm and enhanced emission at 482 nm, as opposed to the 385 nm and 445 nm of the free dye.

TL;DR: The LiAc/SS‐DNA/PEG method was shown to be more effective than other treatments known to make cells transformable and caused tighter binding of 32P‐labelled plasmid DNA than did double‐stranded (DS) carrier.