A systematic survey identifies prions and illuminates sequence features of prionogenic proteins
Simon Alberti,Randal Halfmann,Oliver D. King,Oliver D. King,Atul Kapila,Susan Lindquist,Susan Lindquist +6 more
TL;DR: A bioinformatic proteome-wide survey for prionogenic proteins in S. cerevisiae found an unexpected amino acid bias in aggregation-prone candidates and discovered that 19 of these could also form prions.
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About: This article is published in Cell. The article was published on 03 Apr 2009. and is currently open access. The article focuses on the topics: Fungal prion.
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Citations
•Journal Article
Prion and non-prion amyloids of the HET-s prion forming domain.
Raimon Sabaté,Ulrich Baxa,Laura Benkemoun,N. Sanchez de Groot,Bénédicte Coulary-Salin,Marie-Lise Maddelein,Laurent Malato,Salvador Ventura,Alasdair C. Steven,Sven J. Saupe +9 more
TL;DR: It is shown that electrostatic interactions are critical for the formation and stability of the infectious prion fold given in the current model and the altered properties of the amyloid assembled at pH 2 may arise from a perturbation in the subunit fold or fibrillar stacking.
5
RNA-Binding and Prion Domains: The Yin and Yang of Phase Separation
Nieves Lorenzo Gotor,Alexandros Armaos,Giulia Calloni,R. Martin Vabulas,Natalia Sanchez de Groot,Gian Gaetano Tartaglia +5 more
TL;DR: In this article, the authors used advanced computational models to predict the phase separation propensity of proteins, and designed a set of experiments to investigate the contributions of Prion-Like Domains and RNA-Binding Domains (RBDs).
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Mapping of Nervous System Diseases via MicroRNAs
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PLETHORA-WOX5 interaction and subnuclear localisation control Arabidopsis root stem cell maintenance
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TL;DR: In this paper, the authors describe the concerted mutual regulation of the key transcription factors WUSCHEL-RELATED HOMEOBOX 5 (WOX5) and PLETHORAs (PLTs) on a transcriptional and protein interaction level.
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