Journal Article10.17116/JNEVRO20181183189-93
[A study on the association of genes for pro-inflammatory cytokines and depression].
T. V. Lezheiko,A. V. Andryushchenko,G. I. Korovaitseva,N. V. Kondratiev,M. V. Gabaeva,E. V. Krikova,Vera Golimbet +6 more
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TL;DR: The results suggest that immune factors may play a role in the development of depression and highlight the role of clinical polymorphism of depression that makes it difficult to form homogenous groups of patients and to select phenotypes for biological studies.
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Abstract: Aim To study the association between proinflammatory cytokine genes and depression. Material and methods IL-1B С-511T and TNF-a G-308A gene polymorphisms were studied in patients diagnosed with depression and age and sex-matched healthy controls. Results and conclusion The IL-1B С-511T and TNF-a G-308A polymorphisms were associated with depression; CC genotype (р=0,001, OR=1.9 CI 1,3-2,7) and GG genotype (р=0,001, OR=3,0 CI 1,8-4,9) were the risk factors. The results suggest that immune factors may play a role in the development of depression. The authors highlight the role of clinical polymorphism of depression that makes it difficult to form homogenous groups of patients and to select phenotypes for biological studies.
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Association of depression with viral load, CD8 T lymphocytes, and natural killer cells in women with HIV infection.
Dwight L. Evans,Thomas R. Ten Have,Steven D. Douglas,David R. Gettes,Mary F. Morrison,Margaret S. Chiappini,Priscilla Brinker-Spence,Carla Job,Delinda E. Mercer,Yan Lin Wang,Dean G. Cruess,Benoit Dubé,Erik A. Dalen,Tiffany Brown,Russell M. Bauer,John M. Petitto +15 more
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