Journal Article10.1021/JA00244A028
A single transition state in the transfer of the methoxycarbonyl group between isoquinoline and substituted pyridines in aqueous solution
Edwin Chrystiuk,Andrew Williams +1 more
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About: This article is published in Journal of the American Chemical Society. The article was published on 01 May 1987. The article focuses on the topics: Isoquinoline & Aqueous solution.
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Citations
Sulfoximines from a Medicinal Chemist's Perspective: Physicochemical and in vitro Parameters Relevant for Drug Discovery.
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Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity.
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TL;DR: The ability to tune the chemical reactivity of this class of organometallic ruthenium arene compounds should be useful in optimizing their design as anticancer agents.
Concerted nucleophilic aromatic substitutions
TL;DR: New and sensitive methodology for measuring carbon kinetic isotope effects now shows that most such substitutions actually occur through concerted mechanisms.
Effective Charge and Transition-state Structure in Solution
TL;DR: In this paper, the concept of effective charge in its application to reactions in solution is introduced, and it is recognized that polar substituent effects on rates and equilibria in solution are easily and reliably obtained, and they constitute one of our most powerful mechanistic tools for studies of reactions in solutions.
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