A simple, efficient synthesis of 2-aryl benzimidazoles using silica supported periodic Acid catalyst and evaluation of anticancer activity.
TL;DR: A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H5IO6-SiO2) as a catalyst has been developed and exhibited potent anticancer activity against MCF7 and HL60 cell lines.
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Abstract: A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H5IO6-SiO2) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup procedure. The synthesized benzimidazoles exhibited potent anticancer activity against MCF7 and HL60 cell lines.
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Sougata Ghosh,Piyush More,Abhishek Derle,Ajay B. Patil,Pramod R. Markad,Adersh Asok,Navanath Kumbhar,Mahemud L. Shaikh,Boppana Ramanamurthy,Vaishali S. Shinde,Dilip D. Dhavale,Balu A. Chopade +11 more
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Anticancer copper pyridine benzimidazole complexes: ROS generation, biomolecule interactions, and cytotoxicity.
TL;DR: DNA studies using agarose gel electrophoresis demonstrate strand cleavage by the complexes in the presence of ascorbate, which is mediated by reactive oxygen species (ROS), indicating that damage by ROS is responsible for the observed activity of the complexes.
95
A review on synthetic approaches of benzimidazoles
Vishwajeet Amar Singh Pardeshi,Narendra Singh Chundawat,Sultan Pathan,Priyal Sukhwal,Tejpal Pal Singh Chundawat,Girdhar Pal Singh +5 more
TL;DR: From the group of heterocyclic compounds, benzimidazoles remain the central focus, which owns the important features as six-five member attached rings having two nitrogen atoms at 1-3 position in s...
58
Facile and Efficient Method for Synthesis of Benzimidazole Derivatives Catalyzed by Zinc Triflate
TL;DR: In this article, the synthesis of benzimidazole derivatives using zinc triflate as an efficient catalyst was reported, and one-pot synthesis of substituted aldehydes derivatives from o-phynelyenediamine and substituted substituted substituted alphabetic derivatives were developed under the same zinc catalyst in ethanol solvent at reflux temperature.
Synthesis, DNA interaction and anticancer activity of 2-anthryl substituted benzimidazole derivatives
Vyankat A. Sontakke,Anup N. Kate,Sougata Ghosh,Piyush More,Rajesh G. Gonnade,Navanath Kumbhar,Anupa A. Kumbhar,Balu A. Chopade,Vaishali S. Shinde +8 more
TL;DR: 2-Anthryl benzimidazole derivatives with hydrogen, carboxyl and benzoyl substituents at the 5th position have been synthesized using a silica supported periodic acid catalyst and the anticancer activity of these target molecules exhibited remarkable activity in the micromolar range.
References
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Karen Spivak,Zalman Amit +1 more
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