Journal Article10.1021/JO00205A004
A simple and mild esterification method for carboxylic acids using mixed carboxylic-carbonic anhydrides
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TL;DR: Esterification par reaction avec des chloroformiates d'alkyle et la triethylamine, en presence de dimethylamino-4 pyridine dans le dichloromethane as mentioned in this paper.
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Abstract: Esterification par reaction avec des chloroformiates d'alkyle et la triethylamine, en presence de dimethylamino-4 pyridine dans le dichloromethane
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Aliphatic cyclic carbonates and spiroorthocarbonates as monomers
TL;DR: In this paper, a review of the synthesis and polymerization of aliphatic cyclic carbonates of different size and type is presented. And the mechanisms of cationic, anionic, coordination and enzymatic polymerization are discussed for obtaining polymers with well-defined structures and oligomers with reactive pendant and end groups.
500
Design and Synthesis of an Orally Bioavailable and Selective Peptide Epoxyketone Proteasome Inhibitor (PR-047)
Han-Jie Zhou,Monette Aujay,Mark K. Bennett,Maya Dajee,Susan Demo,Ying Fang,Mark Nguyen Ho,Jing Jiang,Christopher J. Kirk,Guy J. Laidig,Evan R. Lewis,Yan Lu,Tony Muchamuel,Francesco Parlati,Eileen R. Ring,Kevin D. Shenk,Jamie Shields,Peter Shwonek,Timothy Friend Stanton,Congcong M. Sun,Catherine Sylvain,Tina M. Woo,Jinfu Yang +22 more
TL;DR: The lead compound, 2-Me-5-thiazole-Ser( OMe)-Ser(OMe)-Phe-ketoepoxide (58) (PR-047), selectively inhibited CT-L activity of both the constitutive proteasome (beta5) and immunoproteasomes (LMP7) and demonstrated an absolute bioavailability of up to 39% in rodents and dogs.
288
Chloroformates in gas chromatography as general purpose derivatizing agents.
TL;DR: Reaction conditions were optimized for various classes of carboxylic acids and a uniquely rapid derivatization of amino acids in aqueous ethanol was shown to be possible and most of the analytes, e.g. acidic metabolites in physiological fluids, could be treated directly in the aqueously matrix.
263
Direct ester condensation from a 1:1 mixture of carboxylic acids and alcohols catalyzed by hafnium(IV) or zirconium(IV) salts
TL;DR: In this paper, the direct condensation of equimolar amounts of carboxylic acids and alcohols could be achieved using hafnium (IV) or zirconium(IV) salts.
209
Di-tert-butyl dicarbonate and 4-(dimethylamino)pyridine revisited. Their reactions with amines and alcohols
Yochai Basel,Alfred Hassner +1 more
TL;DR: In reactions of aliphatic alcohols with BOC2O/DMAP, carbonic-carbonic anhydride intermediates are isolated for the first time, which helps explain the formation of symmetrical carbonates in addition to the O-BOC products.
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