A Shift from Reversible to Irreversible X Inactivation Is Triggered during ES Cell Differentiation

TL;DR: How plants defend against invasive nucleic acids and focus on the continual evolutionary battle between plants and viruses is described and the importance of controlling transposon activity is outlined.

TL;DR: Embryonic Stem Cells as a Model to Study Transcriptional Regulation Transcription Factors Governing ESC Pluripotency TranscriptionALRegulatory Network Technologies for Dissecting the Trans transcriptional Regulatory Network.

TL;DR: Different kinds of evidence that link the histone variant macroH2A to the increased stability of repressed states are discussed, focusing on developmentally regulated X chromosome inactivation and repression of autosomal pluripotency genes, where macroH1A may help maintain the long-term stability of the differentiated state of somatic cells.

TL;DR: This review summarizes and integrates findings on XCI findings with a particular focus on the redundant yet mutually reinforcing pathways that enable long-term transcriptional repression throughout the soma, including an exploration of concurrent epigenetic changes acting in parallel within two distinct compartments of the inactive X.

TL;DR: It is reported that the activity of Oct4 is essential for the identity of the pluripotential founder cell population in the mammalian embryo and also determines paracrine growth factor signaling from stem cells to the trophectoderm.

TL;DR: Adding doxycycline to HeLa cells that constitutively synthesized the transactivator and that contained an appropriate, stably integrated reporter unit rapidly induced gene expression more than a thousandfold.

TL;DR: This gene, called XIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation, and is described as an X-linked gene with a novel expression pattern.