Journal Article10.1016/J.IJCARD.2005.11.109
A role for matrix metalloproteinase-9 in the hemodynamic changes following acute pulmonary embolism.
Geisa M. Fortuna,Lívia Figueiredo-Lopes,Carlos A. Dias-Junior,Raquel F. Gerlach,Jose E. Tanus-Santos +4 more
TL;DR: It is shown that doxycycline attenuates APE-induced pulmonary hypertension, and indicates that MMP-9 has a role in APE, which may be a pharmacological target inAPE.
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About: This article is published in International Journal of Cardiology. The article was published on 02 Jan 2007. The article focuses on the topics: Pulmonary hypertension & Pulmonary artery.
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Citations
Functional polymorphisms in the promoter of the matrix metalloproteinase-9 (MMP-9) gene are not linked with significant plasma MMP-9 variations in healthy subjects.
Caroline Demacq,Vivian B. Vasconcellos,Andrea M. Marcaccini,Raquel F. Gerlach,Wilson A. Silva,Jose E. Tanus-Santos +5 more
TL;DR: Findings suggest that functional polymorphisms in the promoter of the MMP-9 gene are not linked with significant plasma M MP-9 variations in healthy subjects, and there are no differences in plasma Mmp-9 levels among the genotype groups or among different haplotypes.
46
Dose-dependent beneficial hemodynamic effects of BAY 41-2272 in a canine model of acute pulmonary thromboembolism.
Stefany Bruno de Assis Cau,Carlos A. Dias-Junior,Marcelo F. Montenegro,Gilberto De Nucci,Edson Antunes,Jose E. Tanus-Santos +5 more
TL;DR: It is suggested that stimulation of soluble guanylate cyclase with low (but not high) doses of BAY 41-2272 produces selective pulmonary vasodilation during acute pulmonary embolism, which may limit its usefulness in larger doses.
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Interethnic differences in the distribution of matrix metalloproteinases genetic polymorphisms are consistent with interethnic differences in disease prevalence.
Riccardo Lacchini,Ingrid F. Metzger,Marcelo R. Luizon,Marilia H. Ishizawa,Jose E. Tanus-Santos +4 more
TL;DR: The interethnic differences being reported here replicate those previously found with smaller number of subjects in the Hapmap or Seattle SNPs data and may help explain the higher prevalence of cancer and cardiovascular diseases in blacks compared with whites.
33
Metalloproteinase inhibition protects against cardiomyocyte injury during experimental acute pulmonary thromboembolism.
Evandro M. Neto-Neves,Carlos A. Dias-Junior,Elen Rizzi,Michele M. Castro,Fabiane Sônego,Raquel F. Gerlach,Jose E. Tanus-Santos +6 more
TL;DR: Evidence is found supporting the idea that acute pulmonary thromboembolism is associated with increased matrix metalloproteinase activities in the right ventricle, which may lead to degradation of sarcomeric proteins, including cardiac troponin I.
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Sildenafil Improves the Beneficial Haemodynamic Effects of Intravenous Nitrite Infusion during Acute Pulmonary Embolism
TL;DR: It is suggested that sildenafil improves the beneficial haemodynamic effects of nitrite during acute pulmonary embolism and blunted the increase in TBARS concentrations caused by acute pulmonaryembolism.
31
References
Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis The Good, the Bad, and the Ugly
TL;DR: Experimental evidence acquired in vitro and in vivo suggests that the major drivers of vascular remodeling, hemodynamics, injury, inflammation, and oxidative stress, regulate MMP expression and activity, and nonspecific MMP inhibition seems to oppose remodeling.
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Biochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9)
Philippe E. Van den Steen,Bénédicte Dubois,Inge Nelissen,Pauline M. Rudd,Raymond A. Dwek,Ghislain Opdenakker +5 more
TL;DR: The ability of gelatinase B to degrade components of the extracellular matrix and to regulate the activity of a number of soluble proteins confers an important role in various physiological and pathological processes, including reproduction, growth, development, inflammation, and vascular and proliferative diseases.
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Right ventricular dysfunction after acute pulmonary embolism: Pathophysiologic factors, detection, and therapeutic implications
TL;DR: The concept of "hemodynamic instability" after PE should be expanded to include right ventricular dilatation and wall motion abnormalities, even among normotensive patients.
312
Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction
TL;DR: There is evidence to suggest that another factor plays an important role, since there is a marked discrepancy between the haemodynamic manifestations of acute pulmonary embolism and the degree of mechanical obstruction.