A Role for IL-27 in Limiting T Regulatory Cell Populations
Elia D. Tait Wojno,Nancy Hosken,Jason S. Stumhofer,Aisling C. O’Hara,Elizabeth A. Mauldin,Qun Fang,Laurence A. Turka,Steven D. Levin,Christopher A. Hunter +8 more
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TL;DR: An indirect role for IL-27 is identified in shaping the Treg pool in a bone marrow chimera model, which correlated with reduced production of IL-2, a vital cytokine for Treg maintenance.
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Abstract: IL-27 is a cytokine that regulates Th function during autoimmune and pathogen-induced immune responses Although previous studies have shown that regulatory T cells (Tregs) express the IL-27R, and that IL-27 inhibits forkhead box P3 upregulation in vitro, little is known about how IL-27 influences Tregs in vivo The studies presented in this article show that mice that overexpress IL-27 had decreased Treg frequencies and developed spontaneous inflammation Although IL-27 did not cause mature Tregs to downregulate forkhead box P3, transgenic overexpression in vivo limited the size of a differentiating Treg population in a bone marrow chimera model, which correlated with reduced production of IL-2, a vital cytokine for Treg maintenance These data identify an indirect role for IL-27 in shaping the Treg pool
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TL;DR: It is outlined how cells might interpret seemingly similar cytokine signals to give rise to the diverse functional outcomes that characterize this cytokine family, and the therapeutic implications of this complexity are discussed.
Homeostatic control of regulatory T cell diversity.
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The immunobiology of interleukin-27.
TL;DR: Although this aspect of IL-27 biology has provided insights into how the immune system prevents hyperactivity in the setting of infectious and autoimmune inflammation, in vaccination and cancer models the stimulatory effects ofIL-27 on CD8(+) T cell function appear prominent.
422
From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines
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The Immunobiology of the Interleukin-12 Family: Room for Discovery.
TL;DR: Significant knowledge gaps are presented, including how similar signals from these cytokines can mediate distinct outcomes, and how a better understanding of the biology of the IL-12 family provides new therapeutic opportunities.
383
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