A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications.
Nagaraju Kerru,Lalitha Gummidi,Suresh Maddila,Kranthi Kumar Gangu,Sreekantha B. Jonnalagadda +4 more
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TL;DR: This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.
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Abstract: The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based heterocycles have been designed. The number of novel N-heterocyclic moieties with significant physiological properties and promising applications in medicinal chemistry is ever-growing. In this review, we consolidate the recent advances on novel nitrogen-containing heterocycles and their distinct biological activities, reported over the past one year (2019 to early 2020). This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.
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Citations
A Novel Method of Coupling In Situ Time-Resolved FTIR and Microwave Irradiation: Application to the Monitoring of Quinoxaline Derivatives Synthesis
Alina Cherniienko,Kacper Kossakowski,Lucjusz Zaprutko,Roman Lesyk,Dorota Olender,Anna Pawełczyk +5 more
TL;DR: A novel method combines microwave irradiation with in situ FTIR spectroscopy for real-time monitoring and optimising nitrogen-heterocycle synthesis, specifically quinoxaline derivatives, using a green approach that accelerates kinetics and reduces trial-and-error optimisation.
A Greener Approach for Synthesis of Quinoline-3-carboxylate Building Block and Their Biological Screening
Kapilkumar Galachar,Ashokbhai R. Rathod,Chandankumar Pashavan,Yogesh Naliapara,Vipul Kataria,Sushil Korgaokar +5 more
TL;DR: Researchers develop a green synthesis method for quinoline-3-carboxylate building blocks using multicomponent reactions and L-proline/ammonium acetate catalysts, followed by biological screening of the synthesized derivatives for potential medicinal applications.
Applications of piperazine scaffold in drug design
Xinyan Peng,Qiushi Chen,Bo Han,Hao Zhang,Jianqi Li,Qingwei Zhang +5 more
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TL;DR: Piperazine scaffold is a promising scaffold for drug design due to its similar properties to other drug molecules and its unique advantages.
Organocatalytic Asymmetric Synthesis of 2,3-Dihydro-4<i>H</i>-imidazol-4-ones via Cyclocondensation of <i>N</i>-Silyl Iminoesters
K. Ogura,Shota Ando,Tsunayoshi Takehara,Takeyuki Suzuki,Shuichi Nakamura +4 more
TL;DR: Researchers developed a chiral phosphoric acid catalyst for the asymmetric synthesis of 2,3-dihydro-4H-imidazol-4-ones via cyclocondensation, achieving high yields and enantioselectivities (up to 99% ee) with broad substrate tolerance.
Efficient Synthesis of Novel Biginelli and Hantzsch Products Sourced from Biorenewable Furfurals Using Gluconic Acid Aqueous Solution as the Green Organocatalyst
Harshitha N Anchan,Prajwal Naik C,Navya Subray Bhat,Muskan Kumari,Saikat Dutta +4 more
TL;DR: The synthesis of novel Biginelli and Hantzsch products from biorenewable furfurals is achieved using gluconic acid aqueous solution as a green organocatalyst.
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