A Response Assessment Platform for Development and Validation of Imaging Biomarkers in Oncology.
Hao Yang,Lawrence H. Schwartz,Binsheng Zhao +2 more
- 01 Dec 2016
- Vol. 2, Iss: 4, pp 406-410
TL;DR: This work presents a volumetric response assessment system developed based on an open-source image-viewing platform (WEASIS) designed using the Model–View–Controller concept, and it offers standard image-Viewing and -manipulation functions, efficient tumor segmentsation and quantification algorithms, and a reliable database containing tumor segmentation and measurement results.
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Abstract: Quantitative imaging biomarkers are increasingly used in both oncology clinical trials and clinical practice aid evaluation of tumor response to novel therapies. To obtain these biomarkers, and to ensure smooth clinical adoption once they have been validated, it is critical to develop reliable computer-aided methods and a workflow-efficient imaging platform for integration in research and clinical settings. Here, we present a volumetric response assessment system developed based on an open-source image-viewing platform (WEASIS). Our response assessment system is designed using the Model-View-Controller concept, and it offers standard image-viewing and -manipulation functions, efficient tumor segmentation and quantification algorithms, and a reliable database containing tumor segmentation and measurement results. This prototype system is currently used in our research laboratory to foster the development and validation of new quantitative imaging biomarkers including the volumetric computed tomography technique as a more accurate and early assessment method of solid tumor response to targeted therapy and immunotherapy.
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Elizabeth Eisenhauer,P. Therasse,Jan Bogaerts,Lawrence H. Schwartz,Daniel J. Sargent,Robert Ford,Janet Dancey,S. Arbuck,S. Gwyther,Margaret M. Mooney,Larry Rubinstein,Lalitha K. Shankar,Lori E. Dodd,Robert M. Kaplan,Denis Lacombe,Jaap Verweij +15 more
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New guidelines to evaluate the response to treatment in solid tumors
Patrick Therasse,Susan G. Arbuck,Elizabeth Eisenhauer,Jantien Wanders,Richard Kaplan,Larry Rubinstein,Jaap Verweij,Martine Van Glabbeke,Allan T. van Oosterom,Michaele C. Christian,S. Gwyther +10 more
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Binsheng Zhao,Geoffrey R. Oxnard,Chaya S. Moskowitz,Mark G. Kris,William Pao,Pingzhen Guo,Valerie M. Rusch,Marc Ladanyi,Naiyer A. Rizvi,Lawrence H. Schwartz +9 more
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Open source software in a practical approach for post processing of radiologic images
Gianluca Valeri,Francesco Antonino Mazza,Stefania Maggi,Daniele Aramini,Luigi La Riccia,Giovanni Mazzoni,Andrea Giovagnoni +6 more
TL;DR: OsiriX appears to be the only program able to perform all the operations taken into consideration, similar to a workstation equipped with proprietary software, allowing the analysis and interpretation of images in a simple and intuitive way.
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