Journal Article10.1111/PAPR.12893
A Randomized Double-Blind Controlled Pilot Study Comparing Leucocyte-Rich Platelet-Rich Plasma and Corticosteroid in Caudal Epidural Injection for Complex Chronic Degenerative Spinal Pain.
Ricardo Ruiz-Lopez,Yu-Chuan Tsai +1 more
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TL;DR: To compare the efficacy and safety between leucocyte‐rich platelet‐rich plasma (LR‐PRP) and corticosteroid in fluoroscopically guided caudal epidural injection for patients with complex chronic lumbar spinal pain.
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Abstract: Objectives To compare the efficacy and safety between leucocyte-rich platelet-rich plasma (LR-PRP) and corticosteroid in fluoroscopically guided caudal epidural injection for patients with complex chronic lumbar spinal pain. Study design A prospective randomized controlled double-blinded study. Methods Fifty eligible patients with complex chronic degenerative spinal pain were randomly assigned with a 1:1 allocation ratio to receive caudal epidural injection of corticosteroid (triamcinolone acetonide, 60 mg) or LR-PRP (isolated from 60 mL autologous blood) under fluoroscopic guidance. Levels of low back pain, quality of life, and complications (or adverse effects) were evaluated at 1, 3, and 6 months after treatment. Pain levels and quality of life were assessed using the VAS and Short Form 36-Item Health Survey (SF-36), respectively. Results No significant difference was shown at baseline between the 2 groups. Compared with the pretreatment values, there were significant reductions in the VAS score in both groups. A significantly lower VAS score at 1-month follow-up was detected in patients who received corticosteroid injection. However, the scores were lower in the LR-PRP group at 3- and 6-month follow-up. SF-36 responses at 6 months showed significant improvement in all domains in the LR-PRP group. There were no complications or adverse effects related to treatment at 6-month follow-up in either group. Conclusions Both autologous LR-PRP and corticosteroid for caudal epidural injections under fluoroscopic guidance are equally safe and therapeutically effective in patients with complex chronic lumbar spinal pain. However, LR-PRP is superior to corticosteroid for a longer pain-relieving effect and improvement in quality of life.
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Citations
Ultrasound-Guided Transforaminal Injections of Platelet-Rich Plasma Compared with Steroid in Lumbar Disc Herniation: A Prospective, Randomized, Controlled Study
TL;DR: Wang et al. as mentioned in this paper compared the efficacy and safety aspects between ultrasound-guided transforaminal injections of platelet-rich plasma (PRP) and steroid in patients who suffer from radicular pain due to lumbar disc herniation.
Advances in Platelet-Rich Plasma Treatment for Spinal Diseases: A Systematic Review
Soya Kawabata,Koji Akeda,Junichi Yamada,Norihiko Takegami,Tatsuhiko Fujiwara,Nobuyuki Fujita,Akihiro Sudo +6 more
TL;DR: Recently, Platelet-rich plasma (PRP) has been widely used for the treatment of musculoskeletal diseases, including spinal diseases, in clinics as mentioned in this paper , and the potential of PRP in repairing intervertebral disc degeneration, promoting bone union in spinal fusion surgeries, and aiding in neurological recovery from spinal cord injury.
Systematic Review of Platelet-Rich Plasma for Low Back Pain
Edilson Silva Machado,Fabiano Pasqualotto Soares,Ernani Vianna de Abreu,Taís Amara da Costa de Souza,Robert Meves,Hans Grohs,Mary A. Ambach,Annu Navani,Renato Bevillaqua de Castro,Daniel Humberto Pozza,José Manuel Peixoto Caldas +10 more
TL;DR: PRP was in general an effective and safe treatment for degenerative LPB, and the quality of the evidence supporting the use of PRP in LBP was graded as level II.
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Platelet Rich Plasma and Platelet-Related Products in the Treatment of Radiculopathy—A Systematic Review of the Literature
Eva Kubrova,Gabriel A. Martinez Alvarez,Yeng F. Her,Robert Pagan-Rosado,Wenchun Qu,Ryan S D'Souza +5 more
TL;DR: A systematic review to evaluate the effectiveness of epidural steroid injections containing platelet rich plasma (PRP), platelet lysate (PL) or plasma rich in growth factors (PRGF) for radicular pain remains lacking as discussed by the authors .
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Platelet-rich plasma and cytokines in neuropathic pain: A narrative review and a clinical perspective.
TL;DR: In this paper, a review of the current knowledge on cytokines in neuropathic pain by taking into consideration both human studies and animal models is presented, highlighting the potential therapeutic effect of platelet-rich plasma (PRP) injection on cytokine imbalance in different neuropathic aetiologies.
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Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial.
Robert J. de Vos,Adam Weir,Hans T. M. van Schie,Sita M A Bierma-Zeinstra,Jan A N Verhaar,Harrie Weinans,Johannes L. Tol +6 more
TL;DR: Among patients with chronic Achilles tendinopathy who were treated with eccentric exercises, a PRP injection compared with a saline injection did not result in greater improvement in pain and activity, and was not significantly different between both groups.
Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial.
TL;DR: A single dose of WBC-filtered PRP in concentrations of 10 times the normal amount is as effective as 2 injections to alleviate symptoms in early knee OA, but the results, however, deteriorate after 6 months.
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Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial Platelet-Rich Plasma Versus Corticosteroid Injection With a 1-Year Follow-up
TL;DR: Treatment of patients with chronic lateral epicondylitis with PRP reduces pain and significantly increases function, exceeding the effect of corticosteroid injection.