Journal Article10.1093/bja/56.11.1267
A protocol for the investigation of malignant hyperpyrexia (mh) susceptibility
378
TL;DR: A protocol for investigating malignant hyperpyrexia (MH) susceptibility has been established, allowing diagnoses of MHS, MHN and MHE.
read more
Abstract: A European Malignant Hyperpyrexia Group has been formed to facilitate exchange of information between centres performing in vitro muscle testing for malignant hyperpyrexia susceptibility. Data have been collected according to a protocol agreed by the Group. Based on these results, test criteria have been established to allow the following diagnoses to be made: MH susceptible (MHS); MH normal (MHN) or MH equivocal (MHE). It is accepted that MHE classified patients will be under permanent review, pending the collection of further data.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Test à la caféine sur fibres pelées: application au diagnostic de la susceptibilité à l'hyperthermie maligne
P. Adnet,M.L. Börtlein,Benoît Tavernier,Y. Nivoche,T. Etchrivi,R. Krivosic-Horber,G. Haudecœur +6 more
TL;DR: Le test des fibres pelees ne peut se substituer au test de contracture in vitro de reference, mais il en conforte les resultats.
1
Malignant Hyperthermia in Austria 1984-1993
Dorrit Heilinger,Eva Donner,Andrea Sauberer,Werner Hackl,Walter Mauritz +4 more
- 01 Jan 1996
TL;DR: The Vienna Malignant Hyperthermia Investigation Unit (which functions as the Austrian National MH Registry) was founded in 1976 and has performed diagnostic testing of MH probands and family members since 1976, with results consistent with the European Protocol.
1
A minimal-invasive metabolic test detects malignant hyperthermia susceptibility in a patient after sevoflurane-induced metabolic crisis.
TL;DR: In the presented case, the use of a novel minimal-invasive metabolic test with intramuscular injection of halothane and caffeine successfully confirmed MH susceptibility and hence might be an alternative for invasive in vitro contracture testing in selected cases.
The Role of the Sympathetic Nervous System in Patients Susceptible to Malignant Hyperthermia
J. Hilary Green,F. Richard Ellis,P. Jane Halsall,Iain T. Campbell +3 more
- 01 Jan 1988
TL;DR: Four major studies have now been carried out at the MH Investigation Unit in Leeds to assess the role of the sympathetic nervous system to physiologic stress.
1
Mitochondrial Disorders in Malignant Hyperthermia
G. Kozak-Ribbens
- 01 Jan 1996
TL;DR: The observation of mitochondrial abnormalities in 25 of 234 patients led us to investigate these patients further by additional adequate tests, and results are in agreement with those of Harriman: whatever the in vitro contracture test results, pathological findings were heterogenous.
1