A prospective follow-up on thyroid function, thyroid autoimmunity and long COVID among 250 COVID-19 survivors
David T W Lui,Kimberly Hang Tsoi,Chi-Ho Lee,Chloe Y Y Cheung,Carol H.Y. Fong,Alan Chun Hong Lee,Anthony Raymond Tam,P.K.P. Pang,Tip Yin Ho,Chun-Yiu Law,Ching-Wan Lam,Kelvin K. W. To,Wing Sun Chow,Yu Cho Woo,Ivan Hung,Kathryn C.B. Tan,Karen S.L. Lam +16 more
TL;DR: In this paper , the authors evaluated the evolution of thyroid function and autoimmunity among COVID-19 survivors over 6 months in relation to interferon beta-1b treatment and long COVID.
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Abstract: We evaluated the evolution of thyroid function and autoimmunity among COVID-19 survivors over 6 months in relation to interferon beta-1b treatment and long COVID. We included COVID-19 survivors managed in a major COVID-19 centre between July 2020 and May 2021 who were reassessed three and/or six months after acute COVID-19. Thyroid function tests (TFTs) and anti-thyroid antibody titres were measured at acute COVID-19, 3-month and 6-month. 250 COVID-19 survivors were included (mean age 52.7 years, 50.4% men). Persistent thyroid function abnormalities were more likely in those with abnormal TFTs in acute COVID-19 (P < 0.001). Among 51 patients with abnormal TFTs in acute COVID-19, 82.4% resolved upon follow-up. Of 199 patients with normal TFTs in acute COVID-19, only 4.5% had incident abnormal TFTs, more likely in interferon-treated patients (P = 0.044) and none clinically overt. Among 129 patients with complete 6-month follow-up for anti-thyroid antibody titres, there was no significant change overall, except for modest increase in anti-thyroid antibody titres among the 84 interferon-treated patients (P < 0.05 at both 3 months and 6 months). Long COVID occurred in 19.5% and 10.4% at 3 and 6 months respectively, where TFTs and anti-thyroid antibody titres were not predictive of its occurrence. Over 6 months, most abnormal TFTs in acute COVID-19 resolved, with no significant incident thyroid dysfunction. SARS-CoV-2 infection did not lead to change in thyroid autoimmunity, while interferon treatment was associated with modest increase in anti-thyroid antibody titres. Thyroid function and anti-thyroid antibodies did not play a significant role in long COVID.
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Citations
Long COVID: Complications, Underlying Mechanisms, and Treatment Strategies
TL;DR: In this article , the authors provide an overview of the main mechanisms by which long Covid induces end-organ damage proposed in recent research studies and review various treatment options, current clinical trials, and other potential therapeutic avenues to control long covid.
24
Thyroid dysfunction in COVID-19.
David T W Lui,Chi Ho Lee,Yu Cho Woo,I. F. Hung,Karen Siu-Ling Lam +4 more
TL;DR: Evidence-based practice recommendations for thyroid function testing during and following COVID-19 and concerning COVID-19 vaccination are proposed and radiological, molecular and histological evidence of thyroid involvement in SARS-CoV-2 infection is examined.
12
Thyroid disturbances after COVID-19 and the effect of vaccination in children: a prospective tri-center registry analysis
V. Herczeg,Réka Garai,Johanna Takács,Fanni Kovács,Andrea Luczay,Erzsébet Hrapka,Péter Krivácsy,É. Hosszu,Nikolett Jusztina Beniczky,Ágnes Németh,Eszter Szabina Szilágyi,A. Pécsi,Zsófia Szabó,Attila J. Szabo,Péter Tóth-Heyn +14 more
TL;DR: Assessment of the prevalence and permanence of thyroid autoimmunity (TA) and dysfunction in children after an acute infection and its potential association with vaccination found no effect on the prevalence of TA and children with preceding COVID-19 might benefit from thyroid screening.
3
Journal Article
Long COVID: Complications, Underlying Mechanisms, and Treatment Strategies
TL;DR: In this article , the authors provide an overview of some of the main mechanisms by which long Covid induces end-organ damage proposed in recent research studies and also review various treatment options, current clinical trials, and other potential therapeutic avenues to control long-covid.
A prospective follow-up of thyroid volume and thyroiditis features on ultrasonography among survivors of predominantly mild to moderate COVID-19
Man Him Matrix Fung,David T W Lui,Keith Wan-Hang Chiu,Sherman H Lee,Chi-Ho Lee,Wing Sun Chow,Alan Chun Hong Lee,Anthony Raymond Tam,P.K.P. Pang,Tip Yin Ho,Carol H.Y. Fong,Connie Hong Nin Loong,Chun-Yiu Law,Kelvin K. W. To,Ching-Wan Lam,Kathryn C.B. Tan,Yu Cho Woo,Ivan Hung,Karen S.L. Lam,Brian Hung-Hin Lang +19 more
TL;DR: In this paper , a follow-up study evaluated the evolution of thyroid volumes and thyroiditis features within the same group of patients 6 months later and found that thyroid volume increased from USG1 to USG2 (11.9 ± 4.8 to 14.5 ± 6.2 mL).
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