Open AccessJournal Article
A perspective on the present contribution of beta-lactamases to bacterial resistance with particular reference to induction of beta-lactamase and its clinical significance.
10
TL;DR: Inducible chromosomally mediated beta-lactamases in species such as Enterobacter, Pseudomonas, Citrobacter and some Serratia have become an increasing problem with more widespread use of beta- lactamase stable cephalosporins.
read more
Abstract: Resistance of bacteria to beta-lactam antibiotics has become a serious problem in the past several decades. Virtually all Staphylococcus aureus, many Haemophilus influenzae, Branhamella catarrhalis, Neisseria gonorrhoeae, many Enterobacteriaceae, many Pseudomonas aeruginosa and Bacteroides species possess beta-lactamases which hydrolyze to varying degree penems, penams, carbapenems, cephems, cephamycins and monobactams. The most common plasmid-mediated beta-lactamase is the so-called TEM beta-lactamase (Richmond Sykes type IIIa) which exists in Haemophilus, Neisseria and many of the Enterobacteriaceae. Techniques to overcome this resistance have been the development of beta-lactamase stable compounds and of beta-lactamase inhibitors. However, inducible chromosomally mediated beta-lactamases in species such as Enterobacter, Pseudomonas, Citrobacter and some Serratia have become an increasing problem with more widespread use of beta-lactamase stable cephalosporins.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
What we may expect from novel antibacterial agents in the pipeline with respect to resistance and pharmacodynamic principles
Karen Bush,Malcolm G. P. Page +1 more
TL;DR: Although the new analogues of existing classes, and novel combinations, have been designed to address specific resistance problems, it is by no means certain than they will not be affected by the general mechanisms of resistance, particularly decreased net flux across the Gram-negative outer membrane.
71
Synergy of ciprofloxacin and azlocillin in vitro and in a neutropenic mouse model of infection.
N. X. Chin,K. Jules,H. C. Neu +2 more
TL;DR: Its additive and/or synergistic effects and expanded spectrum of activity against streptococci, methicillin-resistant staphylococci and JK corynebacteria may provide an alternative to traditional therapy.
43
Susceptibility of bacterial isolates to β-lactam antibiotics from U.S. clinical trials over a 5-year period
R E Kessler,Joan Fung-Tomc +1 more
TL;DR: The activity of cefepime against a diverse group of gram-positive and gram-negative (1987-1991) bacteria isolates demonstrates the excellent activity of C. freundii and E. aerogenes isolates, which were often resistant to other cephalosporins.
37
Relation between beta-lactamase producing bacteria and patient characteristics in chronic obstructive pulmonary disease (COPD).
TL;DR: An increased number of antibiotic courses is related to a higher incidence of beta-lactamase producing bacteria and more patients had hospital admissions in the beta L+ group.
31
β-Lactam Resistance in the 21st Century
George A. Jacoby,Karen Bush +1 more
- 01 Jan 2005
TL;DR: β-Lactamases are ancient enzymes, widespread in the microbial world, that in recent years have coevolved with β-lactam antibiotics as aminopenicillins, cephalosporins,cephamycins, oxyimino-cephalosporin, monobactams, and carbapenems have been developed to target new pathogens or to overcome existing resistance.
29