A novel method for the synthesis of 6-bromo-2-(3,4-dichlorophenyl)imidazo[1,2-a]pyridine using microwave irradiation
TL;DR: In this paper, a simple and novel route to the synthesis of imidazopyridines was developed, which involves the synthesis 6-bromo-2-(3,4-dichlorophenyl)imidazo[1,2-a]pyridine (3) by using microwave irradiation.
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Abstract: A simple and novel route to the synthesis of imidazopyridines was developed. The present work involves the synthesis of 6-bromo-2-(3,4-dichlorophenyl)imidazo[1,2-a]pyridine (3) by using microwave irradiation. The synthesized compound (3) was well characterized by NMR, IR, LCMS and elemental analysis.
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Citations
Toxicity of Methyl tert-butyl ether (MTBE) on the male reproductive system under cold conditions
Igor Zavgorodnij,Walerij Kapustnik,Ruslan Batschinskij,Beatrice Thielmann,Irina Böckelmann +4 more
- 01 Mar 2013
TL;DR: In this article, the effect of methyl tert-butyl ether (MTBE) on the reproductive system of laboratory animals exposed directly to MTBE was compared under thermal comfort (25 ± 2 °C) or cold (cold stress) conditions.
3
Toxische Wirkung von Methyltertiärbutylether (MTBE) auf das männliche Reproduktionssystem unter Kältebedingungen
Igor Zavgorodnij,Walerij Kapustnik,Ruslan Batschinskij,Beatrice Thielmann,Irina Böckelmann +4 more
- 01 Mar 2013
TL;DR: In this paper, the effect of methyl tert-butyl ether (MTBE) on the reproductive system of laboratory animals exposed directly to MTBE was compared under thermal comfort (25 ± 2 °C) or cold (cold stress) conditions.
Toxizität von Methyl-tert-butylether auf innere Organe von Versuchstieren unter Kältebedingungen
Igor Zavgorodnij,Beatrice Thielmann,Walerij Kapustnik,Ruslan Batschinskij,J. Batschinskaja,Irina Böckelmann +5 more
- 01 Sep 2019
TL;DR: In this article, the histologische Untersuchung der inneren Organe von Ratten sowohl unter thermischer Behaglichkeit als also unter Kalte was carried out.
Benzimidazoles and Imidazo[1,2-a]pyridines : Biological Activities, Method of Synthesis and Perspectives on Combination of Deuce Pharmacophore
01 Mar 2023
TL;DR: In this paper , the synthesis and medicinal significance of benzimidazoles and imidazopyridines for their development as lead molecules with improved therapeutic efficiencies are discussed.
Benzimidazoles and Imidazo[1,2-a]pyridines : Biological Activities, Method of Synthesis and Perspectives on Combination of Deuce Pharmacophore
24 Jan 2023
TL;DR: In this paper , the synthesis and medicinal significance of benzimidazoles and imidazopyridines for their development as lead molecules with improved therapeutic efficiencies are discussed.
References
Synthesis of polysubstituted imidazo[1,2-a]pyridines via microwave-assisted one-pot cyclization/Suzuki coupling/palladium-catalyzed heteroarylation.
Jamal Koubachi,Saïd El Kazzouli,Sabine Berteina-Raboin,Abderrahim Mouaddib,Gérald Guillaumet +4 more
TL;DR: A new and efficient method for the synthesis of 2,3,6-trisubstituted imidazo[1,2-a]pyridine derivatives using a microwave-assisted one-pot, two-step Suzuki/heteroarylation or one- Pot, three-step cyclization/Suzuki/heterOarylation was developed.
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Bis-cationic heteroaromatics as macrofilaricides: synthesis of bis-amidine and bis-guanylhydrazone derivatives of substituted imidazo[1,2-a]pyridines.
Richard J. Sundberg,Sujay Biswas,Krishna Kumar Murthi,Donna Rowe,John W. McCall,Michael T. Dzimianski +5 more
TL;DR: A series of guanylhydrazone, amidine, and hydrazone derivatives of 2-phenylimidazo[1,2-a]pyridine have been prepared and evaluated for macrofilarial activity against Acanthocheilonema viteae and Brugia pahangi in jirds.
24
(hetero)arylation of 6-halogenoimidazo[1,2-a]pyridines differently substituted at C(2): Influence of the 2-substituent on the Suzuki cross-coupling reaction
Cecile Enguehard,Maud Hervet,Isabelle Thery,Jean‐Louis Renou,Florence Fauvelle,Alain Gueiffier +5 more
TL;DR: The Suzuki-type cross-coupling was shown to proceed efficiently on 6-bromo-2-methyl- and 2-(4-fluorophenyl)imidazo[1,2-a]pyridines, whereas the 6-Br derivative unsubstituted at C(2) appeared to be poorly reactive.
23
Imidazo[1,2-a]pyridines with potent activity against herpesviruses.
TL;DR: Synthesis of a series of 2-aryl-3-pyrimidyl-imidazo[1,2-a]pyridines with potent activity against herpes simplex viruses is described.