A novel method for structure-based prediction of ion channel conductance properties

TL;DR: It is proposed that the BoNT HC–LC complex embedded in the membrane is a transmembrane chaperone, a dynamic structural device that prevents aggregation and achieves translocation of the LC, similar to the protein conducting/translocating channels of the endoplasmic reticulum, mitochondria and chloroplasts.

TL;DR: It is demonstrated that the membrane-associated import receptor Pex5p together with its docking partner Pex14p forms a gated ion-conducting channel which can be opened to a diameter of about 9 nm by the cytosolic receptor–cargo complex.

TL;DR: Interactions between Tc75 and different peptides show that Toc75 itself is able to differentiate between these peptides and the recognition is based on both conformational and electrostatic interactions.

TL;DR: In this article, aufbau solcher tubularer strukturen nutzen biologische Systeme ausgiebig die Selbstassoziation and Selb-organisation molekularer Einheiten.

TL;DR: Comparisons can now be made between the kinetics of the ionic conductances as described by Hodgkin & Huxley, and the steady-state distribution and kinetic changes of the charged controlling particles, which should lead to useful conclusions about the intramolecular organization of the sodium channels and the conformational changes that take place under the influence of the electric field.

TL;DR: A complete atomic model for bacteriorhodopsin between amino acid residues 8 and 225 has been built and suggests that pK changes in the Schiff base must act as the means by which light energy is converted into proton pumping pressure in the channel.

TL;DR: This monograph provides a state-ofthe-art rrview of a “decade of A13 rescarch” for both the clinical and basic science investigator concrrned with this major challenge.

TL;DR: The design, synthesis and characterization of a new class of organic nanotubes based on rationally designed cyclic polypeptides are reported, which may have possible applications in inclusion chemistry, catalysis, molecular electronics and molecular separation technology.