A New Hypoglycemic Prenylated Indole Alkaloid N-Oxide from Endophytic Fungus Pallidocercospora crystalline
TL;DR: A new prenylated indole alkaloid (Penicimutamide C Noxide) and six known alkaloids were isolated from an endophytic fungus Pallidocercospora crystallina as discussed by the authors .
read more
Abstract: A new prenylated indole alkaloid—Penicimutamide C N-oxide (1), a new alkaloid penicimutamine A (2), along with six known alkaloids were isolated from an endophytic fungus Pallidocercospora crystallina. A simple and accurate method was used to determine the N-O bond in the N-oxide group of 1. By using a β-cell ablation diabetic zebrafish model, compounds 1, 3, 5, 6 and 8 showed significantly hypoglycemic activities under the concentration of 10 μM. Further studies revealed that compounds 1 and 8 lowered the glucose level through promoting glucose uptake in zebrafish. In addition, all eight compounds showed no acute toxicity, teratogenicity, nor vascular toxicity in zebrafish under the concentrations range from 2.5 μΜ to 40 μM. Importantly, these results provide new lead compounds for the development of antidiabetes strategies.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Potential application of secondary metabolites in diabetes
Abhik Paul,Arnab Sarkar,Ajeya Samanta,AKASH DE,Sai Satyaprakash Mishra,Rinki Prasad Bhagat,Enjamul Hoque,Avik Maji,Sanmoy Karmakar,Tapan Kumar Maity +9 more
- 25 Oct 2025
References
Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis
TL;DR: Prenylated indole alkaloids are hybrid natural products derived from prenyl diphosphates and tryptophan or its precursors and widely distributed in filamentous fungi, especially in the genera Penicillium and Aspergillus of ascomycota.
441
Zebrafish as a Model for Obesity and Diabetes
TL;DR: Zebrafish is an attractive model system for studying metabolic diseases because of the functional conservation in lipid metabolism, adipose biology, pancreas structure, and glucose homeostasis and is also suited for identification of novel targets associated with the risk and treatment of obesity and diabetes in humans.
Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived aspergillus sp.
Yousong Ding,Jeffrey R. de Wet,James D. Cavalcoli,Shengying Li,Thomas J. Greshock,Thomas J. Greshock,Kenneth A. Miller,Kenneth A. Miller,Jennifer M. Finefield,Jennifer M. Finefield,James D. Sunderhaus,James D. Sunderhaus,Timothy J. McAfoos,Timothy J. McAfoos,Sachiko Tsukamoto,Robert M. Williams,Robert M. Williams,David H. Sherman +17 more
TL;DR: The results establish the early steps for creation of the prenylated indole alkaloid structure and suggest a scheme for the biosynthesis of stephacidin and notoamide metabolites, providing the first genetic and biochemical insights for understanding the structural diversity of this important family of fungal alkaloids.
120
Naturally occurring plant isoquinoline N-oxide alkaloids: their pharmacological and SAR activities
TL;DR: The role of isoquinoline N-oxides alkaloids as an important source of leads for drug discovery is emphasized and some additional SAR (structure-activity relationship) activities are predicted, which point toward new possible applications of these compounds.
88
Indium-Mediated Reduction of Hydroxylamines to Amines
TL;DR: A novel and simple procedure for reduction of hydroxylamines to the corresponding amines by means of indium powder in aqueous media is reported and applicability to one-pot reactions and isoxazolidine N-O bond reduction is demonstrated.
70