Journal Article10.1006/JSBI.1996.0004
A new generation of the IMAGIC image processing system.
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TL;DR: IMAGIC's novel angular reconstitution approach allows for the rapid determination of three-dimensional structures of uncrystallized molecules to high resolution.
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About: This article is published in Journal of Structural Biology. The article was published on 01 Jan 1996.
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Citations
Structure of dimeric mitochondrial ATP synthase: novel F0 bridging features and the structural basis of mitochondrial cristae biogenesis.
TL;DR: The structure of the dimeric F1F0-ATP synthase complex isolated from bovine heart mitochondria by transmission electron microscopy has an overall conic appearance that is consistent with the proposed role of theDimeric enzyme in mitochondrial cristae biogenesis.
The small heat-shock protein, αb-crystallin, has a variable quaternary structure
TL;DR: The variable quaternary structure of alphaB-crystallin is consistent with the polydisperse size of the assembly and the previously observed subunit exchange between multimers, and may facilitate binding of target proteins in up to stoichiometric ratios.
Structural Probing of a Protein Phosphatase 2A Network by Chemical Cross-Linking and Mass Spectrometry
Franz Herzog,Abdullah Kahraman,Daniel Boehringer,Raymond H. Mak,Andreas Bracher,Thomas Walzthoeni,Alexander Leitner,Martin Beck,Franz-Ulrich Hartl,Nenad Ban,Lars Malmström,Ruedi Aebersold +11 more
TL;DR: This study establishes XL-MS as an integral part of hybrid structural biology approaches for the analysis of endogenous protein complexes by gaining distance restraints on a modular interaction network of protein complexes affinity-purified from human cells by applying an adaptedXL-MS protocol.
Bsoft: Image and Molecular Processing in Electron Microscopy
TL;DR: A generalized functionality for reading the tag-base STAR (self-defining text archiving and retrieval) parameter file format is implemented as a mechanism to exchanging parameters between different packages.
Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins
Shee-Mei Lok,Kostyuchenko,Grant E. Nybakken,Heather A. Holdaway,Anthony J. Battisti,Soila Sukupolvi-Petty,Dagmar Sedlak,Daved H. Fremont,Paul R. Chipman,John T. Roehrig,Michael S. Diamond,Richard J. Kuhn,Michael G. Rossmann +12 more
TL;DR: The monoclonal antibody 1A1D-2 has been shown to strongly neutralize dengue virus serotypes 1, 2 and 3, primarily by inhibiting attachment to host cells, and a crystal structure of its antigen binding fragment (Fab) complexed with domain III of the viral envelope glycoprotein, E, showed that the epitope would be partially occluded in the known structure of the mature d Dengue virus.
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TL;DR: A 7-Å resolution map of the purple membrane has been obtained by electron microscopy of tilted, unstained specimens and shows that Lipid bilayer regions fill the spaces between the protein molecules.
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Multivariate descriptive statistical analysis
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Angular reconstitution: a posteriori assignment of projection directions for 3D reconstruction.
TL;DR: In this article, a method of "angular reconstitution" is described, which allows the a posteriori determination of the relative angular orientations of the projections and thus enables the 3D reconstruction of the object to be calculated.
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Exact filters for general geometry three dimensional reconstruction
George Harauz,M. Van Heel +1 more
TL;DR: The authors decrit une approche heuristique pour calculer les fonctions filtres qui sont exactes pour chaque projection dans toute geometrie de reconstruction donnee.
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