A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock.
Xiaowei Jin,Lauren P. Shearman,David R. Weaver,Mark J. Zylka,Geert J. De Vries,Steven M. Reppert +5 more
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TL;DR: Luciferase reporter gene assays indicate that the transcriptional machinery of the core clockwork directly regulates a clock-controlled output rhythm.
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About: This article is published in Cell. The article was published on 08 Jan 1999. and is currently open access. The article focuses on the topics: CLOCK Proteins & E-box.
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Citations
Depolarization and Neurotransmitter Regulation of Vasopressin Gene Expression in the Rat Suprachiasmatic Nucleus In Vitro
TL;DR: It is found that vasoactive intestinal peptide and a VPAC2 (VIP receptor subtype 2) receptor-specific agonist, Ro-25-1553, are the most effective ligands tested in evoking a cAMP–mitogen-activated protein kinase signal transduction cascade leading to an increase in VP gene transcription in the SCN.
17
Chrono-Drug Discovery and Development Based on Circadian Rhythm of Molecular, Cellular and Organ Level
TL;DR: The role of the molecular clock in the time-dependent dosing changes in the therapeutic effect and safety of a drug and the possibility of drug discovery and development based on the molecular Clock are introduced.
Evaluation of mouse urinary bladder smooth muscle for diurnal differences in contractile properties.
Rachel White,Betsir G. Zemen,Zulqarnain Khan,Jenna R. Montgomery,Gerald M. Herrera,Andrea L. Meredith +5 more
TL;DR: The results suggest that autonomous clocks in UBSM make only a limited contribution to the integrated control of diurnal micturition patterns, and identify a diurnal difference for one contractile parameter of bladder muscle.
Circadian expression of clock and screening of clock-controlled genes in peripheral lymphocytes of rat.
TL;DR: The circadian pattern of Clock and genes mediated by the Clock was investigated in peripheral lymphocytes of rats and understanding of clock-mediated genes may lead to a new direction in drug design for control of circadian rhythms.
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The Cell-Autonomous Clock of VIP Receptor VPAC2 Cells Regulates Period and Coherence of Circadian Behavior
TL;DR: VPAC2-expressing cells are a distinct, functionally powerful subset of the SCN circuit, contributing to computation of ensemble period and maintenance of circadian robustness, and this findings extend the understanding ofSCN circuit topology.
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References
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Nicholas Gekakis,David Staknis,David Staknis,David Staknis,Hubert B. Nguyen,Hubert B. Nguyen,Hubert B. Nguyen,Fred C. Davis,Fred C. Davis,Fred C. Davis,Lisa D. Wilsbacher,Lisa D. Wilsbacher,Lisa D. Wilsbacher,David P. King,David P. King,David P. King,Joseph S. Takahashi,Joseph S. Takahashi,Joseph S. Takahashi,Charles J. Weitz,Charles J. Weitz,Charles J. Weitz +21 more
TL;DR: CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity.
2K
Mutagenesis and Mapping of a Mouse Gene, Clock, Essential for Circadian Behavior
Martha Hotz Vitaterna,David P. King,Anne Marie Chang,Jon M. Kornhauser,Phillip L. Lowrey,J. David McDonald,J. David McDonald,William F. Dove,Lawrence H. Pinto,Fred W. Turek,Joseph S. Takahashi +10 more
TL;DR: The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals.
Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms
TL;DR: It is suggested that the SCN contains a large population of autonomous, single-cell circadian oscillators, and that synapses formed in vitro are neither necessary for operation of these oscillators nor sufficient for synchronizing them.
1.5K
Positional cloning of the mouse circadian clock gene.
David P. King,Yaliang Zhao,Ashvin M. Sangoram,Lisa D. Wilsbacher,Minoru Tanaka,Marina P. Antoch,Thomas D.L. Steeves,Martha Hotz Vitaterna,Jon M. Kornhauser,Jon M. Kornhauser,Phillip L. Lowrey,Fred W. Turek,Joseph S. Takahashi +12 more
TL;DR: CLOCK represents the second example of a PAS domain-containing clock protein (besides Drosophila PERIOD), which suggests that this motif may define an evolutionarily conserved feature of the circadian clock mechanism.
1.4K
The late elongated hypocotyl Mutation of Arabidopsis Disrupts Circadian Rhythms and the Photoperiodic Control of Flowering
Robert J. Schaffer,Nicola Ramsay,Alon Samach,Sally Corden,Joanna Putterill,Isabelle A. Carré,George Coupland +6 more
TL;DR: The dominant late elongated hypocotyl (lhy) mutation of Arabidopsis disrupted circadian clock regulation of gene expression and leaf movements and caused flowering to occur independently of photoperiod.
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