A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock.

TL;DR: The evidence linking circadian rhythms, clock genes and adipose biology is reviewed, gaps in understanding are highlighted, and avenues for future research are suggested.

TL;DR: This review provides examples of how research findings within the sleep field have been translated between animal models, healthy volunteers and patient populations with particular focus on the serotonergic system.

TL;DR: In this paper, the role of E-box elements in regulating behavioral rhythmicity and tim gene expression was investigated in Drosophila, where the first intron of the tim gene was investigated through cell culture experiments.

TL;DR: Findings suggest that clock genes, especially Per1, may be involved in TCDD activation of AhR signaling pathways.

TL;DR: The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals.

TL;DR: It is suggested that the SCN contains a large population of autonomous, single-cell circadian oscillators, and that synapses formed in vitro are neither necessary for operation of these oscillators nor sufficient for synchronizing them.

TL;DR: CLOCK represents the second example of a PAS domain-containing clock protein (besides Drosophila PERIOD), which suggests that this motif may define an evolutionarily conserved feature of the circadian clock mechanism.

TL;DR: The dominant late elongated hypocotyl (lhy) mutation of Arabidopsis disrupted circadian clock regulation of gene expression and leaf movements and caused flowering to occur independently of photoperiod.