Journal Article10.1088/0031-9155/38/6/001
A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distributions of dose and clonogenic cell density
Steve Webb,Alan E. Nahum +1 more
TL;DR: This paper extends one particular model of tumour control probability (TCP) to incorporate a variable clonogenic cell density while at the same time assuming a constant 2 Gy fraction size and a uniform radiosensitivity throughout the treatment.
read more
Abstract: Most calculations of the biological effect of radiation on tumours assume that the clonogenic cell density is uniform even if account is taken of non-uniform dose distribution. In practice tumours will almost certainly have a non-uniform clonogenic cell density. This paper extends one particular model of tumour control probability (TCP) to incorporate a variable clonogenic cell density while at the same time assuming a constant 2 Gy fraction size and a uniform radiosensitivity throughout the treatment. Since there are virtually no in vivo data on the variation of density we consider some model situations. One clear conclusion is that a large reduction in clonogenic cell density at the edges of a tumour would permit only a very modest decrease in dose if the TCP is not to be reduced. In general the effect on TCP is a complicated function of the variation in both dose and clonogenic cell density. We give the equations which enable both to be included.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
On Voxel Based Iso‐Tumor‐Control Probability and Iso‐Complication Maps for Selective Boosting and Selective Avoidance Intensity‐Modulated Radiotherapy
Yusung Kim,Wolfgang A. Tomé +1 more
TL;DR: It is believed as the need for functional image guided treatment planning grows, voxel based iso-TCP and iso-Complication maps will become an important tool to assess the integrity of such treatment plans.
Comparative analysis of mathematical models describing radiobiological processes in radiotherapy
Е. С. Сухих,Leonid Sukhikh,O. M. Stakhova,Ya. N. Sutygina,В. В. Розанов +4 more
Les big data, généralités et intégration en radiothérapie
C. Le Fèvre,L. Poty,Georges Noël +2 more
TL;DR: With these new concepts, still at the preliminary stage, it is possible to create a personalized medicine which is always more secure and reliable.
The role of intensity-modulated radiotherapy in the treatment of parotid tumors.
TL;DR: IMRT is a suitable means for treating cancer of the parotid, and a five-field class solution is proposed; it produced substantial sparing of organs at risk and higher UTCPs than 3D-CRT and should enable dose escalation.
Outcome of conventional radiotherapy in small centrally located tumours or lymph nodes: minimal toxicity, remarkable survival but challenging loco-regional control.
Marianne Marquard Knap,S. Khan,A. A. Khalil,D. S. Møller,L. Hoffmann +4 more
TL;DR: Conventional RT for patients with small central lung tumours or solitary lymph nodes is feasible, and toxicity was low with no grade 4–5 events, and only stage showed significant impact on OS and DFS.
References
Optimization by simulated annealing of three-dimensional conformal treatment planning for radiation fields defined by a multileaf collimator.
TL;DR: This paper provides a method of optimizing the choice of beamweights based on the well known optimization technique of simulated annealing and shows that the dose matrix resulting from the latter optimization is closer to the dose prescription than that obtained by using either an optimal set of single weights per field or uniform beamweights.
214
•Book
The Physics of Three Dimensional Radiation Therapy: Conformal Radiotherapy, Radiosurgery and Treatment Planning
Steve Webb,William Powers +1 more
- 01 Jan 1993
TL;DR: This chapter discusses 3D radiation therapy treatment planning for conformal radiotherapy with a multileaf collimator, and important developments for contextual framing of conformal Radiotherapy.
155
Dose-effect relations for tumour control and complication rate after fast neutron therapy for pelvic-tumours.
TL;DR: A steep dose-effect curve was found for local tumour control as well as for the risk of complications after treatment of bladder and rectal cancers and the implication for neutron therapy is discussed.
61
Optimization by simulated annealing of three-dimensional, conformal treatment planning for radiation fields defined by a multileaf collimator: II. Inclusion of two-dimensional modulation of the x-ray intensity.
TL;DR: It is shown that including spatial modulation leads to a wider separation between the dose-volume histograms of the target volume and organs at risk, and is quantified in terms of the tumour control probability at constant normal tissue complication probability.
Clinically relevant optimization of 3-D conformal treatments.
Radhe Mohan,Gikas S. Mageras,Bernard Baldwin,Linda J. Brewster,G.J. Kutcher,Steven A. Leibel,Chandra Burman,C. Clifton Ling,Zvi Fuks +8 more
TL;DR: In this paper a method of computer-aided optimization of 3-D conformal treatment plans is presented which incorporates models to predict the clinical consequences of resulting dose distributions which indicate lower normal tissue complications and higher tumor control.