A microrobotic system guided by photoacoustic computed tomography for targeted navigation in intestines in vivo
Zhiguang Wu,Lei Li,Yiran Yang,Peng Hu,Yang Li,Yang Li,So-Yoon Yang,Lihong V. Wang,Wei Gao +8 more
- 24 Jul 2019
- Vol. 4, Iss: 32
403
TL;DR: The integration of the newly developed microrobotic system and PACT enables deep imaging and precise control of the micromotors in vivo and promises practical biomedical applications, such as drug delivery.
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Abstract: Recently, tremendous progress in synthetic micro/nanomotors in diverse environment has been made for potential biomedical applications. However, existing micro/nanomotor platforms are inefficient for deep tissue imaging and motion control in vivo. Here, we present a photoacoustic computed tomography (PACT)–guided investigation of micromotors in intestines in vivo. The micromotors enveloped in microcapsules are stable in the stomach and exhibit efficient propulsion in various biofluids once released. The migration of micromotor capsules toward the targeted regions in intestines has been visualized by PACT in real time in vivo. Near-infrared light irradiation induces disintegration of the capsules to release the cargo-loaded micromotors. The intensive propulsion of the micromotors effectively prolongs the retention in intestines. The integration of the newly developed microrobotic system and PACT enables deep imaging and precise control of the micromotors in vivo and promises practical biomedical applications, such as drug delivery.
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Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe
Junjie Yao,Kaberniuk Aa,Lei Li,Daria M. Shcherbakova,Ruiying Zhang,Lidai Wang,Lidai Wang,Guo Li,Vladislav V. Verkhusha,Vladislav V. Verkhusha,Lihong V. Wang +10 more
TL;DR: A reversibly switchable nonfluorescent bacterial phytochrome for use in multiscale photoacoustic imaging, BphP1, with the most red-shifted absorption among genetically encoded probes is described, which enabled differential imaging with substantially decreased background signals, enhanced detection sensitivity, increased penetration depth and improved spatial resolution.
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Enteric Micromotor Can Selectively Position and Spontaneously Propel in the Gastrointestinal Tract
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TL;DR: An enteric micromotor system capable of precise positioning and controllable retention in desired segments of the GI tract is demonstrated and acts as a robust nanobiotechnology tool for site-specific GI delivery.
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Oral, ultra–long-lasting drug delivery: Application toward malaria elimination goals
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TL;DR: An oral, ultra–long-acting capsule that dissolves in the stomach and deploys a star-shaped dosage form that releases drug while assuming a geometry that prevents passage through the pylorus yet allows passage of food, enabling prolonged gastric residence is developed.
CsxWO3 Nanorods Coated with Polyelectrolyte Multilayers as a Multifunctional Nanomaterial for Bimodal Imaging-Guided Photothermal/Photodynamic Cancer Treatment
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