A Mechanism for Cell-Cycle Regulation of MAP Kinase Signaling in a Yeast Differentiation Pathway
Shelly Catherine Strickfaden,Matthew J. Winters,Giora Ben-Ari,Rachel E. Lamson,Mike Tyers,Mike Tyers,Peter M. Pryciak +6 more
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TL;DR: A mechanism and physiological benefit of restricting antiproliferative signaling to G1 is defined, which suggests that Ste5 acts as a sensor for high G1 CDK activity and is an integration point for both external and internal signals.
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About: This article is published in Cell. The article was published on 09 Feb 2007. and is currently open access. The article focuses on the topics: Cyclin-dependent kinase & Ste5.
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Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs).
Francois Xavier Theillet,Andres Binolfi,Tamara Frembgen-Kesner,Karan S. Hingorani,Mohona Sarkar,Ciara Kyne,Conggang Li,Peter B. Crowley,Lila M. Gierasch,Gary J. Pielak,Adrian H. Elcock,Anne Gershenson,Philipp Selenko +12 more
TL;DR: This work has learned about the unexpected intracellular stability of disordered proteins, their roles in integrating post-translational protein modifications in cell signaling and about their functions in regulatory processes ranging from transcription to cell fate decisions.
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References
Genetic Control of the Cell Division Cycle in Yeast
TL;DR: Two features which distinguish the cell cycle of Saccharomyces cerevisiae from most other eukaryotes are particularly useful for an analysis of the gene functions that control the cell division cycle.
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TL;DR: The present method is general and affords a quantitative description of cellular differences at the level of protein expression and modification, thus providing information that is critical to the understanding of complex biological phenomena.
The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions
Stuart McLaughlin,Alan Aderem +1 more
TL;DR: For MARCKS, and perhaps other proteins, phosphorylation of serines within its basic cluster reduces the electrostatic attraction, producing translocation of the protein from the membrane to the cytosol by a simple 'electrostatic switch' mechanism.
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MAP kinase pathways.
Maosong Qi,Elaine A. Elion +1 more
TL;DR: Mitogen-activated protein kinase (MAPK) pathways regulate diverse processes ranging from proliferation and differentiation to apoptosis.
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Cyclin-dependent kinases regulate the antiproliferative function of Smads
TL;DR: It is shown that Smad3 is a major physiological substrate of the G1 cyclin-dependent kinases CDK4 and CDK2, and that CDK phosphorylation of Smad 3 inhibits its transcriptional activity and antiproliferative function.