Journal Article10.1002/ACR.20298
A longitudinal study to explain the pain-depression link in older adults with osteoarthritis.
Gillian A. Hawker,Monique A. M. Gignac,Elizabeth M. Badley,Aileen M. Davis,M.R. French,Ye Li,Anthony V. Perruccio,J. Denise Power,Joanna E. M. Sale,Wendy Lou +9 more
TL;DR: To evaluate whether osteoarthritis (OA) pain determines depressed mood, taking into consideration fatigue and disability and controlling for other factors is evaluated.
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Abstract: Objective
To evaluate whether osteoarthritis (OA) pain determines depressed mood, taking into consideration fatigue and disability and controlling for other factors.
Methods
In a community cohort with hip/knee OA, telephone interviews assessed OA pain and disability (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]), fatigue (Multidimensional Fatigue Symptom Inventory), depressed mood (Center for Epidemiologic Studies Depression Scale), and covariates (demographics, self-rated health, comorbidity, pain coping, pain catastrophizing, and social support) at 3 time points over 2 years. Drawing on previous research, a path model was developed to test the interrelationships among the key concepts (pain, depression, fatigue, disability) over time, controlling for covariates.
Results
The baseline mean age was 75.4 years; 78.5% of the subjects were women, 37.2% were living alone, and 15.5% had ≥3 comorbid conditions. WOMAC scores indicated moderate OA symptoms and disability. From the final model with 529 subjects, adjusting for covariates, we found that current OA pain strongly predicted future fatigue and disability (both short and long term), that fatigue and disability in turn predicted future depressed mood, that depressed mood and fatigue were interrelated such that depressed mood exacerbated fatigue and vice versa, and that fatigue and disability, but not depressed mood, led to worsening of OA pain.
Conclusion
Controlling for other factors, OA pain determined subsequent depressed mood through its effect on fatigue and disability. These effects led to worsening of pain and disability over time. These results support the need for improved pain management in OA to prevent or attenuate the downstream effects of pain on disability and mood.
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Citations
Mania reduces perceived pain intensity in patients with chronic pain: preliminary evidence from retrospective archival data
Ian A. Boggero,Jonathan D Cole +1 more
TL;DR: Perceptions of reduced pain intensity during mania or hypomania may contribute to a cycle of increased activity during manic episodes, which may increase pain over time.
Neuropathic pain in end-stage hip and knee osteoarthritis: differential associations with patient-reported pain at rest and pain on activity
J.D. Power,Anthony V. Perruccio,Anthony V. Perruccio,Rajiv Gandhi,Rajiv Gandhi,Christian Veillette,Christian Veillette,J.R. Davey,J.R. Davey,K. Syed,K. Syed,Nizar N. Mahomed,Nizar N. Mahomed,Yoga Raja Rampersaud,Yoga Raja Rampersaud +14 more
TL;DR: Findings support that possible neuropathic pain is experienced by a notable proportion of patients with end-stage hip and knee OA and is more strongly associated with pain at rest than pain on activity, particularly in men.
Longitudinal association between pain, and depression and anxiety over four years.
Marloes M. J. G. Gerrits,Harm W.J. van Marwijk,Patricia van Oppen,Henriëtte E. van der Horst,Brenda W.J.H. Penninx +4 more
TL;DR: This study largely confirms synchrony of change between depression, anxiety and pain, however, even after depression and anxiety remission, subjects report higher pain ratings over time.
The effectiveness of exercise therapy and education plus cognitive behavioral therapy, alone or in combination with total knee arthroplasty in patients with knee osteoarthritis – study protocol for the MultiKnee trial
Maren Falch Lindberg,Arild Aamodt,Mona Badawy,Ingvild B. Bergvad,Petter Borchgrevink,Ove Furnes,Caryl Gay,Stig Heir,Inger Holm,Kari Indrekvam,Nina Kise,Bjørn Lau,Jon Magnussen,Tor Kjetil Nerhus,Turid Rognsvåg,Daniil E. Rudsengen,Tone Rustøen,Søren T. Skou,Jan Stubberud,Milada S. Småstuen,Anners Lerdal +20 more
TL;DR: This randomized controlled trial investigates the effectiveness of exercise therapy and internet-delivered cognitive behavioral therapy, alone or in combination with total knee arthroplasty, in patients with knee osteoarthritis, aiming to optimize outcomes and provide evidence-based treatment recommendations.
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