Journal Article10.1002/ACR.20298
A longitudinal study to explain the pain-depression link in older adults with osteoarthritis.
Gillian A. Hawker,Monique A. M. Gignac,Elizabeth M. Badley,Aileen M. Davis,M.R. French,Ye Li,Anthony V. Perruccio,J. Denise Power,Joanna E. M. Sale,Wendy Lou +9 more
TL;DR: To evaluate whether osteoarthritis (OA) pain determines depressed mood, taking into consideration fatigue and disability and controlling for other factors is evaluated.
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Abstract: Objective
To evaluate whether osteoarthritis (OA) pain determines depressed mood, taking into consideration fatigue and disability and controlling for other factors.
Methods
In a community cohort with hip/knee OA, telephone interviews assessed OA pain and disability (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]), fatigue (Multidimensional Fatigue Symptom Inventory), depressed mood (Center for Epidemiologic Studies Depression Scale), and covariates (demographics, self-rated health, comorbidity, pain coping, pain catastrophizing, and social support) at 3 time points over 2 years. Drawing on previous research, a path model was developed to test the interrelationships among the key concepts (pain, depression, fatigue, disability) over time, controlling for covariates.
Results
The baseline mean age was 75.4 years; 78.5% of the subjects were women, 37.2% were living alone, and 15.5% had ≥3 comorbid conditions. WOMAC scores indicated moderate OA symptoms and disability. From the final model with 529 subjects, adjusting for covariates, we found that current OA pain strongly predicted future fatigue and disability (both short and long term), that fatigue and disability in turn predicted future depressed mood, that depressed mood and fatigue were interrelated such that depressed mood exacerbated fatigue and vice versa, and that fatigue and disability, but not depressed mood, led to worsening of OA pain.
Conclusion
Controlling for other factors, OA pain determined subsequent depressed mood through its effect on fatigue and disability. These effects led to worsening of pain and disability over time. These results support the need for improved pain management in OA to prevent or attenuate the downstream effects of pain on disability and mood.
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Citations
The PROMISⓇ-Plus-Osteoarthritis of the Knee (OAK) profile measure integrates generic and condition-specific content to enhance relevance and efficiency.
Susan Yount,Michael A. Kallen,Karen E. Schifferdecker,Kathleen L. Carluzzo,Lynn M. Marshall,Kathryn Schabel,William J. Robb,David W. Manning,Elliott S. Fisher,David Cella +9 more
TL;DR: The Patient-Reported Outcomes Measurement Information System (PROMIS)-Plus-Osteoarthritis of the Knee (OAK) profile integrates universal PROMIS items with knee-specific items across 13 domains as discussed by the authors.
A Machine Learning Approach to Identify Predictors of Potentially Inappropriate Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Use in Older Adults with Osteoarthritis.
Jayeshkumar Patel,Amit Ladani,Nethra Sambamoorthi,Traci LeMasters,Nilanjana Dwibedi,Usha Sambamoorthi,Usha Sambamoorthi +6 more
TL;DR: In this paper, the authors examined the prevalence and predictors of potentially inappropriate NSAIDs use in older adults (age > 65) with OA using machine learning with real-world data from Optum De-identified Clinformatics® Data Mart.
Impact of pain and catastrophizing on the long-term course of depression in the general population: the HUNT pain study.
Mari Glette,Tore C. Stiles,Mark P. Jensen,Tom Ivar Lund Nilsen,Petter C. Borchgrevink,Tormod Landmark +5 more
TL;DR: The results suggest that when pain intensity or catastrophizing change, depressive symptoms change in the same direction, and they appear to be mutually reinforcing determinants for chronic depression.
Factors affecting pain and physical functions in patients with knee osteoarthritis: An observational study
TL;DR: In this paper , the role of various factors in pain and physical functions in patients with knee osteoarthritis was examined, including age, BMI, sex, and Kellgren-Lawrence (K/L) radiographic grade.
Systematic review of the Multidimensional Fatigue Symptom Inventory-Short Form
Kristine A. Donovan,Kevin Stein,Kevin Stein,Morgan S. Lee,Corinne R. Leach,Corinne R. Leach,Onaedo Ilozumba,Paul B. Jacobsen +7 more
TL;DR: Findings demonstrate the positive psychometric properties of the MFSI-SF, provide evidence for its usefulness in medically ill and nonmedically ill individuals, and support its use in future studies.
References
Cutoff criteria for fit indexes in covariance structure analysis : Conventional criteria versus new alternatives
Li-tze Hu,Peter M. Bentler +1 more
TL;DR: In this article, the adequacy of the conventional cutoff criteria and several new alternatives for various fit indexes used to evaluate model fit in practice were examined, and the results suggest that, for the ML method, a cutoff value close to.95 for TLI, BL89, CFI, RNI, and G...
95.8K
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
TL;DR: The CES-D scale as discussed by the authors is a short self-report scale designed to measure depressive symptomatology in the general population, which has been used in household interview surveys and in psychiatric settings.
•Book
The global burden of disease: a comprehensive assessment of mortality and disability from diseases injuries and risk factors in 1990 and projected to 2020.
Christopher J L Murray,Alan D. Lopez +1 more
- 01 Jan 1996
TL;DR: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors" and use historical trends in main determinants to project mortality and disease burden forward to 2020.
8K
•Journal Article
Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.
TL;DR: WOMAC is a disease-specific purpose built high performance instrument for evaluative research in osteoarthritis clinical trials and fulfil conventional criteria for face, content and construct validity, reliability, responsiveness and relative efficiency.
8K
The Pain Catastrophizing Scale: Development and validation.
TL;DR: In this paper, the Pain Catastrophizing Scale (PCS) was administered to 425 undergraduates and a three component solution comprising (a) rumination, (b) magnification, and (c) helplessness.
7.3K
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