Journal Article10.1021/JA404649M
A highly specific fluorescent probe for hypochlorous acid and its application in imaging microbe-induced HOCl production.
395
TL;DR: FBS is designed as a new fluorescent HOCl probe which has high selectivity, sensitivity, and short response time in a broad range of pH, and the "dual-lock" structure of FBS has an advantage of eliminating interferences from other ROS/RNS.
read more
Abstract: Oxidative stress induced by reactive oxygen species (ROS) plays crucial roles in a wide range of physiological processes and is also implicated in various diseases, including cancer, chronic inflammatory diseases, and neurodegenerative disorders. Among the various ROS, hypochlorous acid (HOCl) plays as a powerful microbicidal agent in the innate immune system. The regulated production of microbicidal HOCl is required for the host to control the invading microbes. However, as a result of the highly reactive and diffusible nature of HOCl, its uncontrolled production may lead to an adverse effect on host physiology. Because of its biological importance, many efforts have been focused on developing selective fluorescent probes to image ROS. However, it is still challenging to design a fluorescent probe with exclusive selectivity toward a particular member of ROS. In the current work, we designed FBS as a new fluorescent HOCl probe which has high selectivity, sensitivity, and short response time in a broad ran...
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
A biocompatible hydrogel as a template for oxidative decomposition reactions: a chemodosimetric analysis and in vitro imaging of hypochlorite
TL;DR: The self-assembly properties of new biocompatible, thermoreversible fluorescent hydrogels, composed of amino acid residues, e.g., l-phenylalanine and l-tyrosine, have been reported and a striking gel-to-sol transition is explicitly noticed in the presence of hypochlorite.
A novel colorimetric and far-red emission ratiometric fluorescent probe for the highly selective and ultrafast detection of hypochlorite in water and its application in bioimaging.
TL;DR: DCOH-FR-OCl, the first probe that can detect OCl- by using two different response signals at an ultrafast speed with a large Stokes shift in fully aqueous media, is reported, and can be successfully employed in the real-time imaging of endogenous and exogenous Ocl- in living cells.
Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models
Na He,Yude Wang,Yan Huang,Yan Huang,Lingxin Chen,Xiaoyan Wang,Xiaoyan Wang,Changjun Lv,Shouwei Yue +8 more
TL;DR: A fluorescent probe, namely BCy-HOCl, is developed for quantitatively monitoring and visualizing HOCl in living cells and in vivo and verified that the HOCl levels conspicuously increased with the severity of the ALI.
Hypochlorite-Mediated Modulation of Photoinduced Electron Transfer in a Phenothiazine-Boron dipyrromethene Electron Donor-Acceptor Dyad: A Highly Water Soluble "Turn-On" Fluorescent Probe for Hypochlorite.
Disha Soni,Naresh Duvva,Deepak Badgurjar,Tapta Kanchan Roy,Surendra Nimesh,Geeta Arya,Lingamallu Giribabu,Raghu Chitta +7 more
TL;DR: The in vitro cell viability assay performed with human embryonic kidney 293 (HEK 293) cells suggested that WS-probe is non-toxic up to 10 μm and implicates the use of the probe for biological applications.
A facile and highly efficient fluorescent turn-on switch strategy based on diketone isomerization and its application in peroxynitrite fluorescent imaging
TL;DR: In this paper, a fluorescent turn-on switch strategy induced by diketone isomerization was reported, which could be used as a trigger for peroxynitrite (ONOO−).
References
H2O2, a necessary evil for cell signaling
TL;DR: Once considered lethal to cells, reactive oxygen species are now known to be involved in redox signaling pathways that may contribute to normal cell function as well as disease progression.
2K
Recent progress on polymer-based fluorescent and colorimetric chemosensors
TL;DR: This tutorial review will cover polymer-based optical chemosensors from 2007 to 2010.
949
Fluorescent and luminescent probes for detection of reactive oxygen and nitrogen species
TL;DR: A critical review highlights recent advances that have been made in the development of fluorescent and luminescent probes employed to monitor various ROS/RNS.
927
A Direct Role for Dual Oxidase in Drosophila Gut Immunity
TL;DR: It is shown that the Drosophila nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme, dual oxidase (dDuox), is indispensable for gut antimicrobial activities, and generates a unique epithelial oxidative burst that limits microbial proliferation in the gut.
818
A selective, cell-permeable optical probe for hydrogen peroxide in living cells.
TL;DR: Peroxyfluor-1 utilizes a boronate deprotection mechanism to provide unprecedented selectivity and optical dynamic range for detecting H2O2 in aqueous solution over similar reactive oxygen species including superoxide, nitric oxide, tert-butyl hydroperoxide, and hydroxyl radical.
647