Journal Article10.1021/JA404649M
A highly specific fluorescent probe for hypochlorous acid and its application in imaging microbe-induced HOCl production.
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TL;DR: FBS is designed as a new fluorescent HOCl probe which has high selectivity, sensitivity, and short response time in a broad range of pH, and the "dual-lock" structure of FBS has an advantage of eliminating interferences from other ROS/RNS.
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Abstract: Oxidative stress induced by reactive oxygen species (ROS) plays crucial roles in a wide range of physiological processes and is also implicated in various diseases, including cancer, chronic inflammatory diseases, and neurodegenerative disorders. Among the various ROS, hypochlorous acid (HOCl) plays as a powerful microbicidal agent in the innate immune system. The regulated production of microbicidal HOCl is required for the host to control the invading microbes. However, as a result of the highly reactive and diffusible nature of HOCl, its uncontrolled production may lead to an adverse effect on host physiology. Because of its biological importance, many efforts have been focused on developing selective fluorescent probes to image ROS. However, it is still challenging to design a fluorescent probe with exclusive selectivity toward a particular member of ROS. In the current work, we designed FBS as a new fluorescent HOCl probe which has high selectivity, sensitivity, and short response time in a broad ran...
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Citations
Hypochlorite-Activated Fluorescence Emission and Antibacterial Activities of Imidazole Derivatives for Biological Applications.
Thanh Chung Pham,Van-Nghia Nguyen,Yeonghwan Choi,Dongwon Kim,Ok-Sang Jung,Dong Joon Lee,Hak Jun Kim,Myung Won Lee,Juyoung Yoon,Hwan Myung Kim,Songyi Lee +10 more
TL;DR: In this article, the use of imidazoline-2-thione (R 1 SR 2 ) probes was reported to detect hypochlorite (HOCl/ClO-) in vivo.
A benzocoumarin-based fluorescent probe for highly specific ultra-sensitive fast detecting endogenous/exogenous hypochlorous acid and its applications
Kui Liu,Su-Jen Huang,Tianrong Li,Jie Sun,Long Fan,Xiaofeng Wang,Huixue Li,Yijia Li,Wei Zhang,Zhen Yang +9 more
- 01 Feb 2022
TL;DR: Wang et al. as mentioned in this paper designed and synthesized a novel based on benzocoumarin fluorescent probe BL for specific detection HOCl, which has brilliant selectivity, high sensitivity (5.64 nM), fast response (60 s), moderate water-solubility.
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A fluorescent probe based on phenothiazine for detection of ClO- with naked-eye color change properties.
TL;DR: In this article , a naked-eye recognition fluorescent probe NNCF was proposed for the detection of hypochlorite (ClO) based on phenothiazine and naphthalimide.
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A nano-detection system based on a chemical probe for early diagnosis of atherosclerosis in situ
TL;DR: Li et al. as mentioned in this paper used a naphthalimide-based fluorescent probe for recognition of cellular reactive oxygen species (ROS), and a platelet membrane with foam cell targeting was wrapped around the probes to prepare two vesicle structures TBNG@Mp and GNTB@Mp.
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The design of multifunctional fluorescent probe for detecting Zn2+/ ClO−/H2O and application in high-security level information encryption
Huizhen Wang,Yunyun Guo,Yan Tang,Qiaolin Tang,Sijie Yin,Zhengfeng Xie,Guanjun Chang +6 more
TL;DR: A multifunctional fluorescent probe (TNB) is designed to selectively detect Zn2+, ClO−, and H2O, with detection limits of 5.03 × 10−9 mol/L (Zn2+), 3.17 × 10−9 mol/L (ClO−), and 1.4 × 10−4 % (H2O), and applied in high-security information encryption technology.
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