Journal Article10.1021/JA404649M
A highly specific fluorescent probe for hypochlorous acid and its application in imaging microbe-induced HOCl production.
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TL;DR: FBS is designed as a new fluorescent HOCl probe which has high selectivity, sensitivity, and short response time in a broad range of pH, and the "dual-lock" structure of FBS has an advantage of eliminating interferences from other ROS/RNS.
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Abstract: Oxidative stress induced by reactive oxygen species (ROS) plays crucial roles in a wide range of physiological processes and is also implicated in various diseases, including cancer, chronic inflammatory diseases, and neurodegenerative disorders. Among the various ROS, hypochlorous acid (HOCl) plays as a powerful microbicidal agent in the innate immune system. The regulated production of microbicidal HOCl is required for the host to control the invading microbes. However, as a result of the highly reactive and diffusible nature of HOCl, its uncontrolled production may lead to an adverse effect on host physiology. Because of its biological importance, many efforts have been focused on developing selective fluorescent probes to image ROS. However, it is still challenging to design a fluorescent probe with exclusive selectivity toward a particular member of ROS. In the current work, we designed FBS as a new fluorescent HOCl probe which has high selectivity, sensitivity, and short response time in a broad ran...
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Citations
A highly specific and sensitive turn-on fluorescence probe for hypochlorite detection and its bioimaging applications
TL;DR: In this article, a highly selectivity and sensitive fluorescent probe, EDPC, based on 3-acetylcoumarin, was synthesized, which could respond to ClO− and exhibit an "off-on" mode in Tris-HCl buffer (pH = 7.2, 10 mM, 50% C2H5OH) solutions.
A thiomorpholine-based fluorescent probe for the far-red hypochlorous acid monitoring.
Małgorzata Świerczyńska,Daniel Słowiński,Radosław Michalski,Jaroslaw Romanski,Radosław Podsiadły +4 more
TL;DR: In this article , a simple thiomorpholine-based fluorescent probe was designed and synthesized by combining thiomorphicoline and nitrobenzenoselenadiazoles fluorophore (NBD-Se).
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A dual-emission fluorescent probe for simultaneous detection of singlet oxygen and hypochlorous acid in lipid droplets
Wanqing Zhao,Shengtao Zhang,Jiali Yan,Pengyue Xu,Bin Li,Yongmin Zhang,Jianli Li,Shaoping Wu +7 more
- 01 Apr 2024
TL;DR: Researchers developed a dual-emission fluorescent probe (DBCC) to simultaneously detect singlet oxygen and hypochlorous acid in lipid droplets, demonstrating high sensitivity, selectivity, and tolerance, enabling endogenous and exogenous imaging in cells and zebrafish.
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Yb-Based Nanoparticles with the Same Excitation and Emission Wavelength for Sensitive in Vivo Biodetection.
TL;DR: A singly Yb doped nanoparticle, that has strong luminescent emission at 975 nm under the excita-tion at the same wavelength, is used as energy donor to construct the detection system and realizes the detection limit at 0.55 ppb as demonstrated in a ClO- detection trial.
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A hydrazone dual-functional fluorescent probe based on carbazole and coumarin groups for the detection of Cu2+ and ClO−: Application in live cell imaging and actual water samples
TL;DR: In this paper , a dual-functional fluorescent probe LL3 based on carbazole and coumarin was synthesized for the detection of Cu 2+ and ClO − .
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