Journal Article10.1021/JA404649M
A highly specific fluorescent probe for hypochlorous acid and its application in imaging microbe-induced HOCl production.
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TL;DR: FBS is designed as a new fluorescent HOCl probe which has high selectivity, sensitivity, and short response time in a broad range of pH, and the "dual-lock" structure of FBS has an advantage of eliminating interferences from other ROS/RNS.
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Abstract: Oxidative stress induced by reactive oxygen species (ROS) plays crucial roles in a wide range of physiological processes and is also implicated in various diseases, including cancer, chronic inflammatory diseases, and neurodegenerative disorders. Among the various ROS, hypochlorous acid (HOCl) plays as a powerful microbicidal agent in the innate immune system. The regulated production of microbicidal HOCl is required for the host to control the invading microbes. However, as a result of the highly reactive and diffusible nature of HOCl, its uncontrolled production may lead to an adverse effect on host physiology. Because of its biological importance, many efforts have been focused on developing selective fluorescent probes to image ROS. However, it is still challenging to design a fluorescent probe with exclusive selectivity toward a particular member of ROS. In the current work, we designed FBS as a new fluorescent HOCl probe which has high selectivity, sensitivity, and short response time in a broad ran...
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Citations
Development of a conjugated polymer-based fluorescent probe for selective detection of HOCl
TL;DR: In this paper, a novel fluorescent probe is fabricated by integrating an aniline unit into the semiconducting conjugated polymer (SCP) nanoparticles, which shows a remarkable fluorescence "turn-off" response to hypochlorous acid (HOCl) due to the conjugation perturbation caused by selective oxidation of anilines groups by HOCl.
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Fluorescent and Colorimetric Chemosensors for Anions, Metal Ions, Reactive Oxygen Species, Biothiols, and Gases
TL;DR: In this article, the contributions of colorimetric and fluorescent chemosensors in detecting anions, metal ions, reactive oxygen species (ROS), reactive nitrogen species, biothiols, and gases are discussed.
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Simultaneous Detection of Intracellular Nitric Oxide and Peroxynitrite by a Surface-Enhanced Raman Scattering Nanosensor with Dual Reactivity.
Hua-Ying Chen,Essy Kouadio Fodjo,Jiang Lei,Shuai Chang,Jia-Bin Li,De-Sheng Zhan,Hai-Xin Gu,Da-Wei Li +7 more
TL;DR: A functional surface-enhanced Raman scattering (SERS) nanosensor which can simultaneously detect nitric oxide and peroxynitrite in living cells is explored and shows that the SERS strategy will be promising in comprehension of the physiological issues related with NO and ONOO-.
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Highly selective turn-on fluorescent probe for hypochlorite and viscosity detection
Lijuan Liang,Yimeng Sun,Chang Liu,Xiaojie Jiao,Ye Shang,Xianshun Zeng,Liancheng Zhao,Jianlong Zhao +7 more
TL;DR: In this article, water-soluble, very fast-responsive fluorescent probes PTZ-TPP and PTZMP based on phenothiazine moiety were developed for detecting HOCl and viscosity simultaneously.
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TL;DR: In this article , the authors presented the first nanoflare-based DNA sensor that could report the distribution of ClO- (a typical marker of AS) in the atherosclerotic plaques.
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