Journal Article10.1016/S0968-0004(97)01155-9
A good antisense molecule is hard to find
TL;DR: To minimize unwanted non-antisense effects, investigators are searching for antisense compounds and ribozymes whose target sites are particularly vulnerable to attack.
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About: This article is published in Trends in Biochemical Sciences. The article was published on 01 Feb 1998.
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Citations
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Suppression of nuclear factor-κB dependent processes using oligonucleotides
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TL;DR: Antisense oligonucleotides which hybridize with nuclear factor-κB (NF-κb) mRNA and methods of using these oligon nucleotides are discussed in this article.
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TL;DR: A method and compound for suppressing an immune response in a mammalian subject, for the treatment or prevention of an autoimmune condition or transplantation rejection are disclosed in this paper, which is an antisense oligonucleotide analog compound having a targeting sequence complementary to a preprocessed CTLA-4 mRNA region identified by SEQ ID No: 22 in SEQ No. 1, spanning the splice junction between intron 1 and exon 2 of the subject.
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TL;DR: In this paper, a kidney disease-associated genes and polypeptides encoded by those genes were provided, along with expression vectors, host cells, and antibodies for diagnosing, treating or preventing diseases of the kidney.
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Stable expression of antisense RNAs targeted to the 5′ non-coding region confers heterotypic inhibition to foot-and-mouth disease virus infection
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Aptamers influence the hemostatic system by activating the intrinsic coagulation pathway in an in vitro Chandler-Loop model.
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TL;DR: It is found that single-stranded aptamers did not have a negative influence on platelets, complement, or inflammation but were able to activate factor XII, kallikrein, and prothrombin in a concentration-dependent manner.
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