A general method applicable to the search for similarities in the amino acid sequence of two proteins

TL;DR: To capture the wide spectrum of approaches concerning this area, a taxonomy has been developed, whose different approaches are explained and major concepts are described in detail.

TL;DR: A method is described to assess directly the number of DNA sequence transformations, evolutionary events, required by a phylogenetic topology without the use of multiple sequence alignment through a generalization of existing character optimization procedures to include insertion and deletion events (indels) in addition to base substitutions.

TL;DR: Functional properties in the development of the oligomeric structures of dehydrogenases and a larger group of enzymes, which are functionally or structurally related possibly because of common nucleotide binding properties are explored.

TL;DR: A 130-kD protein that coimmunoprecipitates with the tight junction protein ZO-1 was bulk purified from Madin-Darby canine kidney cells and subjected to partial endopeptidase digestion and amino acid sequencing, providing the basis for screening canine cDNA libraries.

TL;DR: A more sensitive method of searching for a homologous relation between two proteins is presented and results for α - and β -hemoglobin, for which the homology is already known, are presented and shown to be consistent.