Journal Article10.1177/1352458510389219
A functional magnetic resonance proof of concept pilot trial of cognitive rehabilitation in multiple sclerosis.
Jaume Sastre-Garriga,J. Alonso,J. Alonso,Marta Renom,María Jesús Arévalo,I. González,Ingrid Galán,Xavier Montalban,Alex Rovira +8 more
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TL;DR: The results of the present study indicate that this cognitive rehabilitation programme increases brain activity in the cerebellum of cognitively impaired patients with MS.
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Abstract: Background: Cognitive impairment is frequent in multiple sclerosis (MS) and lacks effective treatment. Cognitive rehabilitation is widely applied in neurorehabilitation settings. Functional magnetic resonance imaging (fMRI) may help in investigating changes in brain activity and provide a tool to assess the efficacy of rehabilitation.Aim: To investigate the effect on brain activity as measured by fMRI of a cognitive rehabilitation programme in patients with MS and cognitive impairment.Method: Fifteen patients with MS and cognitive impairment and five healthy subjects were recruited. Neuropsychological assessments were performed in patients with MS at study entry and after rehabilitation to assess cognitive changes. fMRI scans were performed at week −5 (baseline), week 0 (immediately before rehabilitation) and week 5 (immediately after rehabilitation). The fMRI paradigm was the Paced Auditory Serial Addition Test (PASAT). The cognitive rehabilitation programme was composed of 15 computer-aided drill and pr...
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Citations
Cognitive dysfunction in multiple sclerosis.
Joana Guimarães,Maria José Sá +1 more
TL;DR: The cognitive domains most commonly impaired in MS (memory, attention, executive functions, speed of information processing, and visual–spatial abilities); the pathophysiological mechanism implied in MS cognitive dysfunction and correlated brain MRI features; the importance of neuropsychological assessment of MS patients in different stages of the disease and the influence of its course on cognitive performance.
Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis
Maria A. Rocca,Maria Pia Amato,Nicola De Stefano,Christian Enzinger,Jeroen J. G. Geurts,Iris-K Penner,Alex Rovira,James F. Sumowski,Paola Valsasina,Massimo Filippi +9 more
TL;DR: Standardised neuropsychological tests that are easy to administer and sensitive to disease-related abnormalities are needed to gain a better understanding of the factors affecting cognitive performance in patients with MS than exists at present.
498
Neuropsychological rehabilitation for multiple sclerosis.
TL;DR: Low-level evidence is found that neuropsychological rehabilitation reduces cognitive symptoms in multiple sclerosis and interventions and outcome measures were heterogeneous, which limited the comparability of the studies.
204
Cognitive function in multiple sclerosis improves with telerehabilitation: Results from a randomized controlled trial
TL;DR: This study provides Class I evidence that adaptive, computer-based cognitive remediation accessed from home can improve cognitive functioning in MS.
Treatment of cognitive impairment in multiple sclerosis: position paper
Maria Pia Amato,Dawn Langdon,Xavier Montalban,Ralph H.B. Benedict,John DeLuca,Lauren B. Krupp,Alan J. Thompson,Giancarlo Comi +7 more
TL;DR: Data linking behavioural therapy, symptomatic treatment or disease modifying treatment, to either reducing cognitive decline or improving impaired cognition are limited and inconsistent.
195
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