A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Katrien Berns,Hugo M. Horlings,Bryan T. Hennessy,Mandy Madiredjo,E. Marielle Hijmans,Karin Beelen,Sabine C. Linn,Ana M. Gonzalez-Angulo,Katherine Stemke-Hale,Michael Hauptmann,Roderick L. Beijersbergen,Gordon B. Mills,Marc J. van de Vijver,René Bernards +13 more
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TL;DR: Assessment of PI3K pathway activation may provide a biomarker to identify patients unlikely to respond to trastuzumab-based therapy, and the combined analysis of PTEN and PIK3CA identified twice as many patients at increased risk for progression compared to PTEN alone.
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About: This article is published in Cancer Cell. The article was published on 16 Oct 2007. and is currently open access. The article focuses on the topics: Trastuzumab & Breast cancer.
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A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1
Qing Xu,Yue Jiang,Yue Jiang,Yu Yin,Yu Yin,Qi Li,Jun He,Yi Jing,Yan Ting Qi,Qian Xu,Wei Li,Bo Lu,Stephen S. Peiper,Bing-Hua Jiang,Bing-Hua Jiang,Ling-Zhi Liu +15 more
TL;DR: It is demonstrated that IGF-IR and IRS1, often overexpressed in BC, are two novel targets of miR-148a/152, and that restoration of microRNAs expression may provide a strategy for therapeutic application to treat BC patients.
Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer
Qing-Bai She,Qing-Bai She,Sofia K. Gruvberger-Saal,Sofia K. Gruvberger-Saal,Matthew Maurer,Yilun Chen,Mervi Jumppanen,Tao Su,Meaghan Dendy,Ying Ka Ingar Lau,Lorenzo Memeo,Hugo M. Horlings,Marc J. van de Vijver,Jorma Isola,Hanina Hibshoosh,Neal Rosen,Ramon Parsons,Lao H. Saal,Lao H. Saal +18 more
TL;DR: This study emphasizes the importance of PI3K/PTEN pathway activity in ER-negative and basal-like breast cancer and supports the future clinical evaluation of combining EGFR andPI3K pathway inhibitors for the treatment of BLBC.
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Future of Personalized Medicine in Oncology: A Systems Biology Approach
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Loss of Phosphatase and Tensin Homolog or Phosphoinositol-3 Kinase Activation and Response to Trastuzumab or Lapatinib in Human Epidermal Growth Factor Receptor 2–Overexpressing Locally Advanced Breast Cancers
Bhuvanesh Dave,Ilenia Migliaccio,M. Carolina Gutierrez,Meng Fen Wu,Gary C. Chamness,Helen Wong,Archana Narasanna,Anindita Chakrabarty,Susan G. Hilsenbeck,Jian Huang,Mothaffar F. Rimawi,Rachel Schiff,Carlos L. Arteaga,C. Kent Osborne,Jenny C. Chang +14 more
TL;DR: Activation of PI3 kinase pathway is associated with trastuzumab resistance, whereas low PTEN predicted for response to lapatinib, and these observations support clinical trials with the combination of both agents.
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Molecular portraits of human breast tumours
Charles M. Perou,Therese Sørlie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,Christian A. Rees,Jonathan R. Pollack,Douglas T. Ross,Hilde Johnsen,Lars A. Akslen,Øystein Fluge,Alexander Pergamenschikov,Cheryl A. Williams,Shirley Zhu,Per Eystein Lønning,Anne Lise Børresen-Dale,Patrick O. Brown,David Botstein +17 more
TL;DR: Variation in gene expression patterns in a set of 65 surgical specimens of human breast tumours from 42 different individuals were characterized using complementary DNA microarrays representing 8,102 human genes, providing a distinctive molecular portrait of each tumour.
Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2
Dennis J. Slamon,Brian Leyland-Jones,Steven Shak,Hank Fuchs,Virginia E. Paton,Alex Bajamonde,Thomas Fleming,Wolfgang Eiermann,Janet M. Wolter,Mark D. Pegram,José Baselga,Larry Norton +11 more
TL;DR: The addition of trastuzumab to chemotherapy was associated with a longer time to disease progression, a higher rate of objective response, a longer duration of response, and a lower rate of death at 1 year.
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