A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis.
Emily A. Mathews,Nicolás Andrés Morgenstern,Verónica C. Piatti,Chunmei Zhao,Sebastian Jessberger,Alejandro F. Schinder,Fred H. Gage +6 more
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TL;DR: It is confirmed that the outside‐in layering of the dentate gyrus continues through adulthood and that early‐born cells constitute most of the adult dentate Gyrus, and that a subpopulation of hippocampal progenitors divides infrequently from early development onward.
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Abstract: New neurons are continuously added throughout life to the dentate gyrus of the mammalian hippocampus. During embryonic and early postnatal development, the dentate gyrus is formed in an outside-in layering pattern that may extend through adulthood. In this work, we sought to quantify systematically the relative position of dentate granule cells generated at different ages. We used 5'-bromo-2'-deoxyuridine (BrdU) and retroviral methodologies to birth date cells born in the embryonic, early postnatal, and adult hippocampus and assessed their final position in the adult mouse granule cell layer. We also quantified both developmental and adult-born cohorts of neural progenitor cells that contribute to the pool of adult progenitor cells. Our data confirm that the outside-in layering of the dentate gyrus continues through adulthood and that early-born cells constitute most of the adult dentate gyrus. We also found that substantial numbers of the dividing cells in the adult dentate gyrus were derived from early-dividing cells and retained BrdU, suggesting that a subpopulation of hippocampal progenitors divides infrequently from early development onward.
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Citations
Regulation and Function of Adult Neurogenesis: From Genes to Cognition
TL;DR: This review summarizes the recent research regarding the process of adult neurogenesis from different perspectives, with particular emphasis on the differentiation and development of new neurons, the regulation of the process by extrinsic and intrinsic factors, and their ultimate function in the hippocampus circuit.
604
Chronic early life stress alters developmental and adult neurogenesis and impairs cognitive function in mice
Eva F.G. Naninck,Lianne Hoeijmakers,Nefeli Kakava-Georgiadou,Astrid Meesters,Stanley E. Lazic,Paul J. Lucassen,Aniko Korosi +6 more
TL;DR: It is indicated that chronic ES has lasting consequences on hippocampal structure and function in mice and suggests that male mice are more susceptible to ES than females, and it is shown that only the hippocampus‐dependent functions depend on changes in neurogenesis, whereas cognitive functions that are not exclusively hippocampus‐ dependent do not.
Influenza infection induces neuroinflammation, alters hippocampal neuron morphology, and impairs cognition in adult mice.
TL;DR: These data provide the first evidence that neuroinflammation and changes in hippocampal structural plasticity may underlie cognitive dysfunction associated with influenza infection, and the heightened inflammatory state concurrent with reduced neurotrophic support could leave the brain vulnerable to subsequent insult following influenza infection.
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Delayed coupling to feedback inhibition during a critical period for the integration of adult-born granule cells
Silvio Gabriel Temprana,Lucas A. Mongiat,Sung M. Yang,Mariela F. Trinchero,Diego Diego D Alvarez,Emilio Kropff,Damiana Giacomini,Natalia Beltramone,Guillermo M. Lanuza,Alejandro F. Schinder +9 more
TL;DR: It is shown that immature GCs can efficiently drive distal CA3 targets but poorly activate proximal interneurons responsible for feedback inhibition (FBI), and a computational model reveals that the delayed coupling of new GCs to FBI could be crucial to achieve a fine-grain representation of novel inputs in the dentate gyrus.
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Wnt signaling in the regulation of adult hippocampal neurogenesis.
TL;DR: Current knowledge on the regulation of adult hippocampal neurogenesis by the Wnt/β-catenin signaling cascade and the potential mechanisms involved in this regulation are reviewed.
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Neurons in the Rat Dentate Gyrus Granular Layer Substantially Increase During Juvenile and Adult Life
TL;DR: These results demonstrate a numerical increase in a neuronal population during adulthood in the mammalian brain in rats 30, 120, 200, and 365 days old.
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