A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells
Gosse Jan Adema,Franca C. Hartgers,R.G.G. Verstraten,E. de Vries,G. Marland,S. Menon,Jessica Foster,Y.Q. Xu,P. Nooyen,Terrill K. McClanahan,Kevin B. Bacon,Carl G. Figdor +11 more
TL;DR: The specific expression of DC-CK1 by dendritic cells at the site of initiation of an immune response, combined with its chemotactic activity for naive T cells, suggests that DC- cK1 has an important rule in the induction of immune responses.
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Abstract: Dendritic cells form a system of highly efficient antigen-presenting cells. After capturing antigen in the periphery, they migrate to lymphoid organs where they present the antigen to T cells1,2. Their seemingly unique ability to interact with and sensitize naive T cells gives dendritic cells a central role in the initiation of immune responses and allows them to be used in therapeutic strategies against cancer, viral infection and other diseases. How they interact preferentially with naive rather than activated T lymphocytes is still poorly understood. Chemokines direct the transport of white blood cells in immune surveillance3,4. Here we report the identification and characterization of a C-C chemokine (DC-CK1) that is specifically expressed by human dendritic cells at high levels. Tissue distribution analysis demonstrates that dendritic cells present in germinal centres and T-cell areas of secondary lymphoid organs express this chemokine. We show that DC-CK1, in contrast to RANTES, MIP-1α and interleukin-8, preferentially attracts naive T cells (CD45RA+). The specific expression of DC-CK1 by dendritic cells at the site of initiation of an immune response, combined with its chemotactic activity for naive T cells, suggests that DC-CK1 has an important rule in the induction of immune responses.
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Citations
Identification and Characterization of DC-SCRIPT, a Novel Dendritic Cell-Expressed Member of the Zinc Finger Family of Transcriptional Regulators
Vassilis Triantis,Dagmar Eleveld Trancikova,Maaike W. G. Looman,Franca C. Hartgers,Richard A.J. Janssen,Gosse J. Adema +5 more
TL;DR: The isolation and characterization of DC-SCRIPT is reported, a novel protein encoded by an 8-kb mRNA that is preferentially expressed in DC that could be involved in transcriptional repression.
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Mycobacterium tuberculosis Induces CCL18 Expression in Human Macrophages
Giovanni Ferrara,Bertram Bleck,Luca Richeldi,Joan Reibman,Leonardo M. Fabbri,William N. Rom,R. Condos +6 more
TL;DR: Up‐regulation of CCL18 and IL‐10 in macrophages by MTB may be involved in the recruitment of naïve T cells in association with local suppressive immunity against intracellular pathogens.
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Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES.
TL;DR: The nucleotide sequences of the MPIF-1 and HCC-2 genes are well conserved, including introns and flanking sequences, except for the middle region of the long first intron, indicating that they have been generated recently in evolutionary terms by duplication.
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The Dendritic Cell-Specific Chemokine, Dendritic Cell-Derived CC Chemokine 1, Enhances Protective Cell-Mediated Immunity to Murine Malaria
TL;DR: The results show for the first time an in vivo role for DC-CK1 in the establishment of primary T cell responses and indicate the potential of this chemokine as an adjuvant for vaccines against malaria as well as other diseases in which cellular immune responses are important.
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Differential regulation of CCL22 gene expression in murine dendritic cells and B cells.
TL;DR: Within the proximal promoter region, potential binding sites for NF-κB, Ikaros, and a putative GC box are identified and identical and distinct proteins contribute to expression of CCL22 in DC and B cells.
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