A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells
Gosse Jan Adema,Franca C. Hartgers,R.G.G. Verstraten,E. de Vries,G. Marland,S. Menon,Jessica Foster,Y.Q. Xu,P. Nooyen,Terrill K. McClanahan,Kevin B. Bacon,Carl G. Figdor +11 more
TL;DR: The specific expression of DC-CK1 by dendritic cells at the site of initiation of an immune response, combined with its chemotactic activity for naive T cells, suggests that DC- cK1 has an important rule in the induction of immune responses.
read more
Abstract: Dendritic cells form a system of highly efficient antigen-presenting cells. After capturing antigen in the periphery, they migrate to lymphoid organs where they present the antigen to T cells1,2. Their seemingly unique ability to interact with and sensitize naive T cells gives dendritic cells a central role in the initiation of immune responses and allows them to be used in therapeutic strategies against cancer, viral infection and other diseases. How they interact preferentially with naive rather than activated T lymphocytes is still poorly understood. Chemokines direct the transport of white blood cells in immune surveillance3,4. Here we report the identification and characterization of a C-C chemokine (DC-CK1) that is specifically expressed by human dendritic cells at high levels. Tissue distribution analysis demonstrates that dendritic cells present in germinal centres and T-cell areas of secondary lymphoid organs express this chemokine. We show that DC-CK1, in contrast to RANTES, MIP-1α and interleukin-8, preferentially attracts naive T cells (CD45RA+). The specific expression of DC-CK1 by dendritic cells at the site of initiation of an immune response, combined with its chemotactic activity for naive T cells, suggests that DC-CK1 has an important rule in the induction of immune responses.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Blocking the recruitment of naive CD4 + T cells reverses immunosuppression in breast cancer.
Shicheng Su,Jian-You Liao,Jiang Liu,Di Huang,Chonghua He,Fei Chen,Lin Bing Yang,Wei Wu,Jianing Chen,Ling Lin,Yunjie Zeng,Nengtai Ouyang,Xiuying Cui,Herui Yao,Fengxi Su,Jian-Dong Huang,Judy Lieberman,Qiang Liu,Erwei Song +18 more
TL;DR: In human breast cancer xenografts in humanized mice, blocking the recruitment of naive CD4+ T cells into tumor by knocking down the expression of PITPNM3, a CCL18 receptor, significantly reduces intratumoral Tregs and inhibits tumor progression, indicating poor prognosis for breast cancer patients.
Macrophage and dendritic cell phenotypic diversity in the context of biomaterials.
TL;DR: The interconnection between innate and adaptive immunity, the comparative and contrasting phenotypes and roles of Mϕs and DCs in immunity, their responses to biomaterials and the strategies to modulate their phenotype for applications in tissue engineering and vaccine delivery are discussed.
194
Monocytes and dendritic cells in a hypoxic environment : Spotlights on chemotaxis and migration
Maria Carla Bosco,Maura Puppo,Fabiola Blengio,Tiziana Fraone,Paola Cappello,Mirella Giovarelli,Luigi Varesio +6 more
TL;DR: This brief review provides an overview of the phenotypic and functional changes triggered by hypoxia in primary monocytes and DCs and discusses the partial overlap existing among mononuclear phagocytes at various differentiation stages in the expression of a cluster of hypoxic-responsive genes coding for regulators of angiogenesis, proinflammatory cytokines/receptors, and inflammatory mediators and implicated in tissue neo-vascularization and cell activation.
183
Identification of human CCR8 as a CCL18 receptor
TL;DR: CCL18 is an endogenous agonist of the human CCR8 receptor that acts as a “spatially reprogrammable” ligand for the H1N1 receptor, which is a major ligand of the H2O2 receptor.
"Lymphoid" chemokine messenger RNA expression by epithelial cells in the chronic inflammatory lesion of the salivary glands of Sjögren's syndrome patients: possible participation in lymphoid structure formation.
Georgina Xanthou,Mary Polihronis,Athanasios G. Tzioufas,Spyros Paikos,Paschalis Sideras,Haralampos M. Moutsopoulos +5 more
TL;DR: The expression pattern of "lymphoid" chemokine mRNA points further to the role of epithelial cells in the pathogenesis of SS and offers new insight into the potential mechanisms that could be involved in leukocyte attraction and in the in situ formation of secondary lymphoid tissue structures.
171
References
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.
TL;DR: Cultured DCs are as efficient as antigen-specific B cells in presenting tetanus toxoid (TT) to specific T cell clones and their efficiency of antigen presentation can be further enhanced by specific antibodies via FcR- mediated antigen uptake.
5.5K
The dendritic cell system and its role in immunogenicity
TL;DR: Dendritic cells are specialized to mediate several physiologic components of immunogenicity such as the acquisition of antigens in tissues, the migration to lymphoid organs, and the identification and activation of antigen-specific T cells.
5K
Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells
Fiorenza Cocchi,Anthony L. DeVico,Alfredo Garzino-Demo,Suresh K. Arya,Robert C. Gallo,Paolo Lusso +5 more
TL;DR: Recombinant human RANTES, Mip-1α, and MIP-1β induced a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) and may have relevance for the prevention and therapy of AIDS.
Proliferating dendritic cell progenitors in human blood.
Nikolaus Romani,S Gruner,D. Brang,Eckhart Kämpgen,Angela Lenz,B Trockenbacher,G Konwalinka,Peter O. Fritsch,Ralph M. Steinman,Gerold Schuler +9 more
TL;DR: Large numbers of DC progenitors are observed in cord blood and in adult blood from healthy donors, which should facilitate future studies of their Fc epsilon RI and CD4 receptors, and their use in stimulating T cell-mediated resistance to viruses and tumors.
Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family
TL;DR: This review has summarized and discussed the available information concerning the regulation and structure of the genes, the structure and biochemical properties of the polypeptide products, their receptors, signal transduction, cell sources, and in vitro as well as in vivo activities of these cytokines.
2K